Pleural mesothelioma classification update

• Published in: Virchows Archiv : an international journal of pathology Vol. 478; no. 1; pp. 59 - 72
• Main Authors: Beasley, Mary Beth, Galateau-Salle, Francoise, Dacic, Sanja
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2021; Springer Nature B.V
• Subjects: Annual review issues from Virchows Archiv; Biomarkers, Tumor - metabolism; Classification; Cyclin-Dependent Kinase Inhibitor p16 - metabolism; Diagnosis; Diagnosis, Differential; Diagnostic systems; Differential diagnosis; Effusion; Genomics; Humans; Immunohistochemistry; Medicine; Medicine & Public Health; Mesothelioma; Mesothelioma, Malignant - diagnosis; Mesothelioma, Malignant - metabolism; Mesothelioma, Malignant - pathology; Pathology; Pleural Neoplasms - diagnosis; Pleural Neoplasms - metabolism; Pleural Neoplasms - pathology; Review and Perspectives; Tumor Suppressor Proteins - metabolism; Tumors; Ubiquitin Thiolesterase - metabolism; Histologic classification; Mesothelioma; Pleura

The 2015 WHO classification of pleural mesotheliomas includes three major histologic subtypes—epithelioid, sarcomatoid, and biphasic. Recent genomic data has supported the need for a more granular and clinically valid classification beyond the three current subtypes. Because of tumor rarity and over...