CD133 + endothelial-like stem cells restore neovascularization and promote longevity in progeroid and naturally aged mice

• Published in: Nature aging Vol. 3; no. 11; pp. 1401 - 1414
• Main Authors: Sun, Shimin, Meng, Yuan, Li, Mingying, Tang, Xiaolong, Hu, Wenjing, Wu, Weiwei, Li, Guo, Pang, Qiuxiang, Wang, Wengong, Liu, Baohua
• Format: Journal Article
• Language: English
• Published: United States Nature Publishing Group 01.11.2023
• Subjects: Aging; Animals; Endothelial Progenitor Cells - pathology; Longevity; Mice; Neovascularization, Pathologic - pathology; Stem cells; Stem Cells - pathology

The stem cell theory of aging dictates that a decline in the number and/or function of stem cells causes tissue degeneration and aging; however, it still lacks unequivocal experimental support. Here, using lineage tracing and single-cell transcriptomics, we identify a population of CD133 bone marrow...