ARID1A has prognostic value in acute myeloid leukemia and promotes cell proliferation via TGF-β1/SMAD3 signaling

• Published in: Clinical and experimental medicine Vol. 23; no. 3; pp. 777 - 785
• Main Authors: Ren, Tianying, Wang, Jing, Tang, Wenqiang, Chen, Dongliang, Wang, Shuang, Zhang, Xiaole, Yang, Dawei
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.07.2023; Springer Nature B.V
• Subjects: Acute myeloid leukemia; Apoptosis; Cell cycle; Cell growth; Cell proliferation; Chromatin remodeling; Hematology; Internal Medicine; Leukemia; Medicine; Medicine & Public Health; Molecular modelling; Oncology; Original Article; Remission; Remission (Medicine); Signal transduction; Smad3 protein; Therapeutic targets; Transforming growth factor-b1; Tumor suppressor genes; Tumorigenesis; AML; Relapse; TGF-β1/ SMAD3; ARID1A; Tumor suppressor

Previous studies have shown that the gene AT-rich interactive domain-containing protein 1A (ARID1A) is a subunit of SWI/SNF chromatin remodeling complex that acts as a tumor suppressor gene in several cancers and plays a vital role in tumorigenesis. However, its biological functions in acute myeloid...