Epigenetic analysis suggests aberrant cerebellum brain aging in old-aged adults with autism spectrum disorder and schizophrenia

• Published in: Molecular psychiatry Vol. 28; no. 11; pp. 4867 - 4876
• Main Authors: Liu, Li, Qi, Xin, Cheng, Shiqiang, Meng, Peilin, Yang, Xuena, Pan, Chuyu, Zhang, Na, Chen, Yujing, Li, Chune, Zhang, Huijie, Zhang, Zhen, Zhang, Jingxi, Cheng, Bolun, Wen, Yan, Jia, Yumeng, Liu, Huan, Zhang, Feng
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.11.2023; Nature Publishing Group
• Subjects: 631/208; 692/699/476/1373; 692/699/476/1799; Age; Aging; Autism; Behavioral Sciences; Biological Psychology; Cerebellum; DNA methylation; Epigenetics; Gender; Genomes; Medicine; Medicine & Public Health; Mental disorders; Neurosciences; Pharmacotherapy; Psychiatry; Schizophrenia

The aberrant aging hypothesis of schizophrenia (SCZ) and autism spectrum disorder (ASD) has been proposed, and the DNA methylation (DNAm) clock, which is a cumulative evaluation of DNAm levels at age-related CpGs, could serve as a biological aging indicator. This study evaluated epigenetic brain agi...