Activation of Beta-adrenergic Receptors Upregulates the Signal-to-Noise Ratio of Auditory Input in the Medial Prefrontal Cortex and Mediates Auditory Fear Conditioning

• Published in: Molecular neurobiology Vol. 61; no. 3; pp. 1833 - 1844
• Main Authors: Xie, Haiting, Tian, Yueqin, Li, Zhongli, Wang, Kaitao, Li, Runtong, Yi, Shang, Chen, Aimin, Chen, Jian, Liu, Jun, Wei, Xuhong, Gao, Xiaoya
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.03.2024; Springer Nature B.V
• Subjects: Adrenergic receptors; Agonists; Biomedical and Life Sciences; Biomedicine; Cell Biology; Conformation; Electrophysiological recording; Fear conditioning; Hearing; Immunohistochemistry; Microinjection; Muscimol; Neurobiology; Neurology; Neurons; Neurosciences; Noise; Norepinephrine; Post traumatic stress disorder; Prefrontal cortex; Western blotting; γ-Aminobutyric acid A receptors; Signal-to-noise ratio; Acoustic fear conditioning; Prelimbic cortex; Single-cell patch clamp recording; β-Adrenergic receptor

Norepinephrine (NE) is involved in auditory fear conditioning (AFC) in posttraumatic stress disorder (PTSD). However, it is still unclear how it acts on neurons. We aimed to investigate whether the activation of the β-adrenergic receptor (β-AR) improves AFC by sensitization of the prelimbic (PL) cor...