Vitamin D increases the efficacy of cisplatin on bladder cancer cell lines

• Published in: Molecular biology reports Vol. 50; no. 1; pp. 697 - 706
• Main Authors: Özgen, Özge, Özen Eroğlu, Güneş, Küçükhüseyin, Özlem, Akdeniz, Nilgün, Hepokur, Ceylan, Kuruca, Serap, Yaylım, İlhan
• Format: Journal Article
• Language: English
• Published: Dordrecht Springer Netherlands 2023; Springer Nature B.V
• Subjects: Animal Anatomy; Animal Biochemistry; Annexin V; Antineoplastic Agents - pharmacology; Antineoplastic Agents - therapeutic use; Apoptosis; Biomedical and Life Sciences; Bladder cancer; Calcitriol; Calcitriol - pharmacology; Cancer; Cancer therapies; Cell Line, Tumor; Chemotherapy; Cisplatin; Cisplatin - pharmacology; Cisplatin - therapeutic use; Cytotoxicity; Flow cytometry; Histology; Humans; Life Sciences; Morphology; Original Article; Tumor cell lines; Urinary Bladder Neoplasms - drug therapy; Urinary Bladder Neoplasms - metabolism; Vitamin D; Vitamin D - pharmacology; Vitamin D - therapeutic use; Vitamins - pharmacology; P-gp; Vitamin D; Calcitriol; T24 cell line; Bladder cancer; Cisplatin; Apoptosis

Background 1,25(OH)2D3(Calcitriol), which is a broad regulatory molecule, plays a role in changing the efficacy of chemotherapeutic drugs. Cisplatin is one of a current standard chemotherapy regimen for bladder cancer. Increasing the effectiveness of the treatment and reducing the side effects to ch...