Bradykinin Receptors Play a Critical Role in the Chronic Post-ischaemia Pain Model

• Published in: Cellular and molecular neurobiology Vol. 41; no. 1; pp. 63 - 78
• Main Authors: Gonçalves, Elaine C. D., Vieira, Graziela, Gonçalves, Tainara R., Simões, Róli R., Brusco, Indiara, Oliveira, Sara M., Calixto, João B., Cola, Maíra, Santos, Adair R. S., Dutra, Rafael C.
• Format: Journal Article
• Language: English
• Published: New York Springer US 2021; Springer Nature B.V
• Subjects: Agonists; Antisense oligonucleotides; Biomedical and Life Sciences; Biomedicine; Bradykinin; Bradykinin receptors; Cell Biology; Chronic pain; Complex regional pain syndrome; Edema; Gene expression; Hyperalgesia; Inflammation; Ischemia; Neurobiology; Neurosciences; Original Research; Pain; Pain perception; Spinal cord; Trauma; Kinins; Inflammation; Inflammatory mediators; Bradykinin receptor antagonists; Chronic pain; Hyperalgesia

Complex regional pain syndrome type-I (CRPS-I) is a chronic painful condition resulting from trauma. Bradykinin (BK) is an important inflammatory mediator required in acute and chronic pain response. The objective of this study was to evaluate the association between BK receptors (B 1 and B 2 ) and...