Regulation of endothelial progenitor cell functions during hyperglycemia: new therapeutic targets in diabetic wound healing

• Published in: Journal of molecular medicine (Berlin, Germany) Vol. 100; no. 4; pp. 485 - 498
• Main Authors: Wan, Gui, Chen, Yangyang, Chen, Jing, Yan, Chengqi, Wang, Cheng, Li, Wenqing, Mao, Renqun, Machens, Hans-Günther, Yang, Xiaofan, Chen, Zhenbing
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2022; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; Diabetes; Diabetes mellitus; Endothelial cells; Human Genetics; Hyperglycemia; Internal Medicine; Molecular Medicine; Molecular modelling; Progenitor cells; Review; Stem cells; Therapeutic targets; Tissue engineering; Wound healing; Hyperglycemia; Wound healing; Diabetes; EPCs

Diabetes is primarily characterized by hyperglycemia, and its high incidence is often very costly to patients, their families, and national economies. Unsurprisingly, the number and function of endothelial progenitor cells (EPCs) decrease in patients resulting in diabetic wound non-healing. As precu...