Changes in liver microRNA expression and their possible regulatory role in energy metabolism-related genes in hibernating black bears

• Published in: Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology Vol. 191; no. 2; pp. 397 - 409
• Main Authors: Nishida, Kazuhei, Shimozuru, Michito, Okamatsu-Ogura, Yuko, Miyazaki, Mitsunori, Soma, Tsukasa, Sashika, Mariko, Tsubota, Toshio
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2021; Springer Nature B.V
• Subjects: Animal Physiology; Animals; Bears; Biochemistry; Biomedical and Life Sciences; Biomedicine; Energy metabolism; Energy Metabolism - genetics; Energy sources; Fatty acids; Fatty-acid synthase; Gene expression; Gene sequencing; Genes; Hibernation; Homeostasis; Human Physiology; Life Sciences; Liver; Liver - metabolism; Metabolism; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Original Paper; Ribonucleic acid; RNA; Transfection; Ursidae - genetics; Zoology; microRNA; Metabolism; Non-coding RNA; Hibernation; Liver; Ursus

Hibernating bears survive up to 6 months without feeding while yet maintaining metabolic homeostasis. We previously reported expression changes in energy metabolism-related genes in the liver of hibernating Japanese black bears. The present study examined the role of microRNAs in the regulation of h...