Changes in liver microRNA expression and their possible regulatory role in energy metabolism-related genes in hibernating black bears

Hibernating bears survive up to 6 months without feeding while yet maintaining metabolic homeostasis. We previously reported expression changes in energy metabolism-related genes in the liver of hibernating Japanese black bears. The present study examined the role of microRNAs in the regulation of h...

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Published inJournal of comparative physiology. B, Biochemical, systemic, and environmental physiology Vol. 191; no. 2; pp. 397 - 409
Main Authors Nishida, Kazuhei, Shimozuru, Michito, Okamatsu-Ogura, Yuko, Miyazaki, Mitsunori, Soma, Tsukasa, Sashika, Mariko, Tsubota, Toshio
Format Journal Article
LanguageEnglish
Published Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2021
Springer Nature B.V
Subjects
Animal Physiology
Animals
Bears
Biochemistry
Biomedical and Life Sciences
Biomedicine
Energy metabolism
Energy Metabolism - genetics
Energy sources
Fatty acids
Fatty-acid synthase
Gene expression
Gene sequencing
Genes
Hibernation
Homeostasis
Human Physiology
Life Sciences
Liver
Liver - metabolism
Metabolism
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
Original Paper
Ribonucleic acid
RNA
Transfection
Ursidae - genetics
Zoology
microRNA
Metabolism
Non-coding RNA
Hibernation
Liver
Ursus
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Abstract Hibernating bears survive up to 6 months without feeding while yet maintaining metabolic homeostasis. We previously reported expression changes in energy metabolism-related genes in the liver of hibernating Japanese black bears. The present study examined the role of microRNAs in the regulation of hepatic gene expression during hibernation. The quantitative analyses revealed significant increases in the expression of 4 microRNAs (miR-221-3p, miR-222-3p, miR-455-3p, and miR-195a-5p) and decreases of 2 microRNAs (miR-122-5p and miR-7a-1-5p) during hibernation. RNA sequencing and in silico target prediction regarding 3 upregulated microRNAs (miR-221-3p, miR-222-3p and miR-455-3p) found 13 target mRNAs with significantly decreased expression during hibernation. The transfection of microRNA mimics into cells showed that miR-222 and miR-455 reduced solute carrier family 16 member 4 ( SLC16A4 ) and fatty acid synthase (FASN ) mRNA expression, respectively. Our results suggest that the increased levels of hepatic miRNA during hibernation (miR-222-3p and miR-455-3p) negatively regulate the expression of targeted genes predicted to be involved in the transport of energy source and de novo fatty acid synthesis, is consistent with a regulatory role of these miRNAs in energy metabolism in hibernating black bears.
AbstractList Hibernating bears survive up to 6 months without feeding while yet maintaining metabolic homeostasis. We previously reported expression changes in energy metabolism-related genes in the liver of hibernating Japanese black bears. The present study examined the role of microRNAs in the regulation of hepatic gene expression during hibernation. The quantitative analyses revealed significant increases in the expression of 4 microRNAs (miR-221-3p, miR-222-3p, miR-455-3p, and miR-195a-5p) and decreases of 2 microRNAs (miR-122-5p and miR-7a-1-5p) during hibernation. RNA sequencing and in silico target prediction regarding 3 upregulated microRNAs (miR-221-3p, miR-222-3p and miR-455-3p) found 13 target mRNAs with significantly decreased expression during hibernation. The transfection of microRNA mimics into cells showed that miR-222 and miR-455 reduced solute carrier family 16 member 4 (SLC16A4) and fatty acid synthase (FASN) mRNA expression, respectively. Our results suggest that the increased levels of hepatic miRNA during hibernation (miR-222-3p and miR-455-3p) negatively regulate the expression of targeted genes predicted to be involved in the transport of energy source and de novo fatty acid synthesis, is consistent with a regulatory role of these miRNAs in energy metabolism in hibernating black bears.
Hibernating bears survive up to 6 months without feeding while yet maintaining metabolic homeostasis. We previously reported expression changes in energy metabolism-related genes in the liver of hibernating Japanese black bears. The present study examined the role of microRNAs in the regulation of hepatic gene expression during hibernation. The quantitative analyses revealed significant increases in the expression of 4 microRNAs (miR-221-3p, miR-222-3p, miR-455-3p, and miR-195a-5p) and decreases of 2 microRNAs (miR-122-5p and miR-7a-1-5p) during hibernation. RNA sequencing and in silico target prediction regarding 3 upregulated microRNAs (miR-221-3p, miR-222-3p and miR-455-3p) found 13 target mRNAs with significantly decreased expression during hibernation. The transfection of microRNA mimics into cells showed that miR-222 and miR-455 reduced solute carrier family 16 member 4 (SLC16A4) and fatty acid synthase (FASN) mRNA expression, respectively. Our results suggest that the increased levels of hepatic miRNA during hibernation (miR-222-3p and miR-455-3p) negatively regulate the expression of targeted genes predicted to be involved in the transport of energy source and de novo fatty acid synthesis, is consistent with a regulatory role of these miRNAs in energy metabolism in hibernating black bears.
Hibernating bears survive up to 6 months without feeding while yet maintaining metabolic homeostasis. We previously reported expression changes in energy metabolism-related genes in the liver of hibernating Japanese black bears. The present study examined the role of microRNAs in the regulation of hepatic gene expression during hibernation. The quantitative analyses revealed significant increases in the expression of 4 microRNAs (miR-221-3p, miR-222-3p, miR-455-3p, and miR-195a-5p) and decreases of 2 microRNAs (miR-122-5p and miR-7a-1-5p) during hibernation. RNA sequencing and in silico target prediction regarding 3 upregulated microRNAs (miR-221-3p, miR-222-3p and miR-455-3p) found 13 target mRNAs with significantly decreased expression during hibernation. The transfection of microRNA mimics into cells showed that miR-222 and miR-455 reduced solute carrier family 16 member 4 (SLC16A4) and fatty acid synthase (FASN) mRNA expression, respectively. Our results suggest that the increased levels of hepatic miRNA during hibernation (miR-222-3p and miR-455-3p) negatively regulate the expression of targeted genes predicted to be involved in the transport of energy source and de novo fatty acid synthesis, is consistent with a regulatory role of these miRNAs in energy metabolism in hibernating black bears.Hibernating bears survive up to 6 months without feeding while yet maintaining metabolic homeostasis. We previously reported expression changes in energy metabolism-related genes in the liver of hibernating Japanese black bears. The present study examined the role of microRNAs in the regulation of hepatic gene expression during hibernation. The quantitative analyses revealed significant increases in the expression of 4 microRNAs (miR-221-3p, miR-222-3p, miR-455-3p, and miR-195a-5p) and decreases of 2 microRNAs (miR-122-5p and miR-7a-1-5p) during hibernation. RNA sequencing and in silico target prediction regarding 3 upregulated microRNAs (miR-221-3p, miR-222-3p and miR-455-3p) found 13 target mRNAs with significantly decreased expression during hibernation. The transfection of microRNA mimics into cells showed that miR-222 and miR-455 reduced solute carrier family 16 member 4 (SLC16A4) and fatty acid synthase (FASN) mRNA expression, respectively. Our results suggest that the increased levels of hepatic miRNA during hibernation (miR-222-3p and miR-455-3p) negatively regulate the expression of targeted genes predicted to be involved in the transport of energy source and de novo fatty acid synthesis, is consistent with a regulatory role of these miRNAs in energy metabolism in hibernating black bears.
Hibernating bears survive up to 6 months without feeding while yet maintaining metabolic homeostasis. We previously reported expression changes in energy metabolism-related genes in the liver of hibernating Japanese black bears. The present study examined the role of microRNAs in the regulation of hepatic gene expression during hibernation. The quantitative analyses revealed significant increases in the expression of 4 microRNAs (miR-221-3p, miR-222-3p, miR-455-3p, and miR-195a-5p) and decreases of 2 microRNAs (miR-122-5p and miR-7a-1-5p) during hibernation. RNA sequencing and in silico target prediction regarding 3 upregulated microRNAs (miR-221-3p, miR-222-3p and miR-455-3p) found 13 target mRNAs with significantly decreased expression during hibernation. The transfection of microRNA mimics into cells showed that miR-222 and miR-455 reduced solute carrier family 16 member 4 ( SLC16A4 ) and fatty acid synthase (FASN ) mRNA expression, respectively. Our results suggest that the increased levels of hepatic miRNA during hibernation (miR-222-3p and miR-455-3p) negatively regulate the expression of targeted genes predicted to be involved in the transport of energy source and de novo fatty acid synthesis, is consistent with a regulatory role of these miRNAs in energy metabolism in hibernating black bears.
Author Sashika, Mariko
Nishida, Kazuhei
Miyazaki, Mitsunori
Shimozuru, Michito
Okamatsu-Ogura, Yuko
Soma, Tsukasa
Tsubota, Toshio
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  givenname: Michito
  surname: Shimozuru
  fullname: Shimozuru, Michito
  email: shimozuru@vetmed.hokudai.ac.jp
  organization: Laboratory of Wildlife Biology and Medicine, Faculty of Veterinary Medicine, Hokkaido University
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  surname: Okamatsu-Ogura
  fullname: Okamatsu-Ogura, Yuko
  organization: Laboratory of Biochemistry, Faculty of Veterinary Medicine, Hokkaido University
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  givenname: Mitsunori
  surname: Miyazaki
  fullname: Miyazaki, Mitsunori
  organization: Department of Physical Therapy, School of Rehabilitation Sciences, Health Sciences University of Hokkaido
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  surname: Soma
  fullname: Soma, Tsukasa
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  surname: Sashika
  fullname: Sashika, Mariko
  organization: Laboratory of Wildlife Biology and Medicine, Faculty of Veterinary Medicine, Hokkaido University
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  givenname: Toshio
  surname: Tsubota
  fullname: Tsubota, Toshio
  organization: Laboratory of Wildlife Biology and Medicine, Faculty of Veterinary Medicine, Hokkaido University
BackLink https://www.ncbi.nlm.nih.gov/pubmed/33459845$$D View this record in MEDLINE/PubMed
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CitedBy_id crossref_primary_10_1371_journal_pone_0263085
crossref_primary_10_1080_10717544_2021_1995081
crossref_primary_10_1152_physiolgenomics_00017_2024
crossref_primary_10_1038_s41598_022_24251_0
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IEDL.DBID U2A
ISSN 0174-1578
1432-136X
IngestDate Fri Jul 11 00:35:22 EDT 2025
Wed Aug 13 03:36:38 EDT 2025
Wed Feb 19 02:25:09 EST 2025
Tue Jul 01 04:23:15 EDT 2025
Thu Apr 24 23:00:03 EDT 2025
Fri Feb 21 02:49:21 EST 2025
IsPeerReviewed true
IsScholarly true
Issue 2
Keywords microRNA
Metabolism
Non-coding RNA
Hibernation
Liver
Ursus
Language English
LinkModel DirectLink
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PQPubID 54170
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crossref_primary_10_1007_s00360_020_01337_7
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PublicationCentury 2000
PublicationDate 20210300
2021-03-00
20210301
PublicationDateYYYYMMDD 2021-03-01
PublicationDate_xml – month: 3
  year: 2021
  text: 20210300
PublicationDecade 2020
PublicationPlace Berlin/Heidelberg
PublicationPlace_xml – name: Berlin/Heidelberg
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PublicationSubtitle Biochemical, Systems, and Environmental Physiology
PublicationTitle Journal of comparative physiology. B, Biochemical, systemic, and environmental physiology
PublicationTitleAbbrev J Comp Physiol B
PublicationTitleAlternate J Comp Physiol B
PublicationYear 2021
Publisher Springer Berlin Heidelberg
Springer Nature B.V
Publisher_xml – name: Springer Berlin Heidelberg
– name: Springer Nature B.V
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  doi: 10.1007/s00424-018-2208-y
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Snippet Hibernating bears survive up to 6 months without feeding while yet maintaining metabolic homeostasis. We previously reported expression changes in energy...
Hibernating bears survive up to 6 months without feeding while yet maintaining metabolic homeostasis. We previously reported expression changes in energy...
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SubjectTerms Animal Physiology
Animals
Bears
Biochemistry
Biomedical and Life Sciences
Biomedicine
Energy metabolism
Energy Metabolism - genetics
Energy sources
Fatty acids
Fatty-acid synthase
Gene expression
Gene sequencing
Genes
Hibernation
Homeostasis
Human Physiology
Life Sciences
Liver
Liver - metabolism
Metabolism
MicroRNAs
MicroRNAs - genetics
MicroRNAs - metabolism
miRNA
Original Paper
Ribonucleic acid
RNA
Transfection
Ursidae - genetics
Zoology
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Title Changes in liver microRNA expression and their possible regulatory role in energy metabolism-related genes in hibernating black bears
URI https://link.springer.com/article/10.1007/s00360-020-01337-7
https://www.ncbi.nlm.nih.gov/pubmed/33459845
https://www.proquest.com/docview/2491437552
https://www.proquest.com/docview/2478774336
Volume 191
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