Revisiting the critical roles of reactive astrocytes in neurodegeneration

• Published in: Molecular psychiatry Vol. 28; no. 7; pp. 2697 - 2706
• Main Authors: Qian, Kang, Jiang, Xiaobing, Liu, Zhi-Qiang, Zhang, Juan, Fu, Peng, Su, Ying, Brazhe, Nadezda A., Liu, Dan, Zhu, Ling-Qiang
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.07.2023; Nature Publishing Group
• Subjects: 631/378; 692/699; 96/21; Alzheimer Disease - pathology; Alzheimer's disease; Amyotrophic lateral sclerosis; Astrocytes; Astrocytes - metabolism; Behavioral Sciences; Biological Psychology; Blood-brain barrier; Blood-Brain Barrier - metabolism; Central nervous system; Disease; Homeostasis; Humans; Huntington Disease; Huntington's disease; Huntingtons disease; Localization; Medicine; Medicine & Public Health; Metabolism; Morphology; Movement disorders; Multiple sclerosis; Nervous system; Neurodegeneration; Neurodegenerative Diseases; Neurological disorders; Neurons; Neurosciences; Neurotoxicity; Parkinson's disease; Pharmacotherapy; Physiology; Psychiatry; Review Article

Astrocytes, an integral component of the central nervous system (CNS), contribute to the maintenance of physiological homeostasis through their roles in synaptic function, K + buffering, blood-brain barrier (BBB) maintenance, and neuronal metabolism. Reactive astrocytes refer to astrocytes undergoin...