Revisiting the critical roles of reactive astrocytes in neurodegeneration

Astrocytes, an integral component of the central nervous system (CNS), contribute to the maintenance of physiological homeostasis through their roles in synaptic function, K + buffering, blood-brain barrier (BBB) maintenance, and neuronal metabolism. Reactive astrocytes refer to astrocytes undergoin...

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Published inMolecular psychiatry Vol. 28; no. 7; pp. 2697 - 2706
Main Authors Qian, Kang, Jiang, Xiaobing, Liu, Zhi-Qiang, Zhang, Juan, Fu, Peng, Su, Ying, Brazhe, Nadezda A., Liu, Dan, Zhu, Ling-Qiang
Format Journal Article
LanguageEnglish
Published London Nature Publishing Group UK 01.07.2023
Nature Publishing Group
Subjects
631/378
692/699
96/21
Alzheimer Disease - pathology
Alzheimer's disease
Amyotrophic lateral sclerosis
Astrocytes
Astrocytes - metabolism
Behavioral Sciences
Biological Psychology
Blood-brain barrier
Blood-Brain Barrier - metabolism
Central nervous system
Disease
Homeostasis
Humans
Huntington Disease
Huntington's disease
Huntingtons disease
Localization
Medicine
Medicine & Public Health
Metabolism
Morphology
Movement disorders
Multiple sclerosis
Nervous system
Neurodegeneration
Neurodegenerative Diseases
Neurological disorders
Neurons
Neurosciences
Neurotoxicity
Parkinson's disease
Pharmacotherapy
Physiology
Psychiatry
Review Article
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Abstract Astrocytes, an integral component of the central nervous system (CNS), contribute to the maintenance of physiological homeostasis through their roles in synaptic function, K + buffering, blood-brain barrier (BBB) maintenance, and neuronal metabolism. Reactive astrocytes refer to astrocytes undergoing morphological, molecular and functional remodelling in response to pathological stimuli. The activation and differentiation of astrocytes are implicated in the pathogenesis of multiple neurodegenerative diseases. However, there are still controversies regarding their subset identification, function and nomenclature in neurodegeneration. In this review, we revisit the multidimensional roles of reactive astrocytes in Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). Furthermore, we propose a precise linkage between astrocyte subsets and their functions based on single-cell sequencing analyses.
AbstractList Astrocytes, an integral component of the central nervous system (CNS), contribute to the maintenance of physiological homeostasis through their roles in synaptic function, K+ buffering, blood-brain barrier (BBB) maintenance, and neuronal metabolism. Reactive astrocytes refer to astrocytes undergoing morphological, molecular and functional remodelling in response to pathological stimuli. The activation and differentiation of astrocytes are implicated in the pathogenesis of multiple neurodegenerative diseases. However, there are still controversies regarding their subset identification, function and nomenclature in neurodegeneration. In this review, we revisit the multidimensional roles of reactive astrocytes in Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). Furthermore, we propose a precise linkage between astrocyte subsets and their functions based on single-cell sequencing analyses.
Astrocytes, an integral component of the central nervous system (CNS), contribute to the maintenance of physiological homeostasis through their roles in synaptic function, K buffering, blood-brain barrier (BBB) maintenance, and neuronal metabolism. Reactive astrocytes refer to astrocytes undergoing morphological, molecular and functional remodelling in response to pathological stimuli. The activation and differentiation of astrocytes are implicated in the pathogenesis of multiple neurodegenerative diseases. However, there are still controversies regarding their subset identification, function and nomenclature in neurodegeneration. In this review, we revisit the multidimensional roles of reactive astrocytes in Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). Furthermore, we propose a precise linkage between astrocyte subsets and their functions based on single-cell sequencing analyses.
Astrocytes, an integral component of the central nervous system (CNS), contribute to the maintenance of physiological homeostasis through their roles in synaptic function, K + buffering, blood-brain barrier (BBB) maintenance, and neuronal metabolism. Reactive astrocytes refer to astrocytes undergoing morphological, molecular and functional remodelling in response to pathological stimuli. The activation and differentiation of astrocytes are implicated in the pathogenesis of multiple neurodegenerative diseases. However, there are still controversies regarding their subset identification, function and nomenclature in neurodegeneration. In this review, we revisit the multidimensional roles of reactive astrocytes in Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), multiple sclerosis (MS) and amyotrophic lateral sclerosis (ALS). Furthermore, we propose a precise linkage between astrocyte subsets and their functions based on single-cell sequencing analyses.
Author Qian, Kang
Zhang, Juan
Su, Ying
Brazhe, Nadezda A.
Zhu, Ling-Qiang
Jiang, Xiaobing
Fu, Peng
Liu, Zhi-Qiang
Liu, Dan
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  surname: Qian
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  givenname: Xiaobing
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  givenname: Juan
  surname: Zhang
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  organization: Department of Pathophysiology, Key Lab of Neurological Disorder of Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology
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  surname: Fu
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  organization: Department of Neurosurgery, Union Hospital, Huazhong University of Science and Technology
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  surname: Su
  fullname: Su, Ying
  organization: Department of Neurology, Union Hospital, Huazhong University of Science and Technology
– sequence: 7
  givenname: Nadezda A.
  surname: Brazhe
  fullname: Brazhe, Nadezda A.
  organization: Biophysics Department, Biological Faculty, Moscow State University
– sequence: 8
  givenname: Dan
  surname: Liu
  fullname: Liu, Dan
  email: liudan_echo@mail.hust.edu.cn
  organization: Department of Medical Genetics, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology
– sequence: 9
  givenname: Ling-Qiang
  orcidid: 0000-0001-9964-9229
  surname: Zhu
  fullname: Zhu, Ling-Qiang
  email: zhulq@mail.hust.edu.cn
  organization: Department of Pathophysiology, Key Lab of Neurological Disorder of Education Ministry, School of Basic Medicine, Tongji Medical College, Huazhong University of Science and Technology
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Snippet Astrocytes, an integral component of the central nervous system (CNS), contribute to the maintenance of physiological homeostasis through their roles in...
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Alzheimer Disease - pathology
Alzheimer's disease
Amyotrophic lateral sclerosis
Astrocytes
Astrocytes - metabolism
Behavioral Sciences
Biological Psychology
Blood-brain barrier
Blood-Brain Barrier - metabolism
Central nervous system
Disease
Homeostasis
Humans
Huntington Disease
Huntington's disease
Huntingtons disease
Localization
Medicine
Medicine & Public Health
Metabolism
Morphology
Movement disorders
Multiple sclerosis
Nervous system
Neurodegeneration
Neurodegenerative Diseases
Neurological disorders
Neurons
Neurosciences
Neurotoxicity
Parkinson's disease
Pharmacotherapy
Physiology
Psychiatry
Review Article
Title Revisiting the critical roles of reactive astrocytes in neurodegeneration
URI https://link.springer.com/article/10.1038/s41380-023-02061-8
https://www.ncbi.nlm.nih.gov/pubmed/37037874
https://www.proquest.com/docview/2884010417
https://search.proquest.com/docview/2799826405
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