MicroRNA-125b alleviates hydrogen-peroxide-induced abnormal mitochondrial dynamics in HT22 cells by inhibiting p53

• Published in: Metabolic brain disease Vol. 36; no. 4; pp. 601 - 608
• Main Authors: Huang, Yan, Deng, Songyun, Ai, Yuhang, Mo, Yunan, Li, Wenchao, Peng, Qianyi, Huang, Li, Zhang, Lina
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2021; Springer Nature B.V
• Subjects: Biochemistry; Biomedical and Life Sciences; Biomedicine; Cell death; Damage; Electron microscopy; Hippocampus; Homeostasis; Hydrogen peroxide; Metabolic Diseases; miRNA; Mitochondria; Neurology; Neurosciences; Oncology; Original Article; Oxidative stress; p53 Protein; Oxidative stress; Micro-RNA 125b; Mitochondrial dynamics; p53

Micro-RNA125b (miR-125b) and tumor protein p53 (p53) are involved in the regulation of mitochondrial dynamics; however, the mechanism of their possible interaction during oxidative stress remains unclear. In this study, we investigated the role and mechanism of miR-125b and p53 in oxidative stress-i...