Plasma exosomal miR-199a-3p downregulates cell proliferation and migration in Hirschsprung’s disease by targeting mTOR

• Published in: Pediatric surgery international Vol. 39; no. 1; p. 54
• Main Authors: Daiyue, Yu, Yang, Yang, Zhaorong, Huang, Yi, Lu, Chen, Wang, Caiyun, Luo, Yuqian, Su, Liucheng, Yang, Kai, Wu
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 19.12.2022; Springer Nature B.V
• Subjects: Cell growth; Cell Proliferation - genetics; Exosomes; Genes; Hirschsprung Disease - genetics; Humans; Medicine; Medicine & Public Health; MicroRNAs; MicroRNAs - genetics; Original Article; Pediatric Surgery; Pediatrics; Plasma; Surgery; TOR Serine-Threonine Kinases - genetics; TOR Serine-Threonine Kinases - metabolism; Hirschsprung's disease; mTOR; Exosomes; miR-199a-3p

Background Plasma exosomal microRNAs have been suggested to be potential biomarkers of disease. However, the exosomal microRNAs in Hirschsprung’s disease (HSCR) are still unclear. In this study, we analyzed the miRNA profiles of HSCR and elucidated the mechanism of the selected miR-199a-3p in the de...