KIR + CD8 + T cells suppress pathogenic T cells and are active in autoimmune diseases and COVID-19

• Published in: Science (American Association for the Advancement of Science) Vol. 376; no. 6590; p. eabi9591
• Main Authors: Li, Jing, Zaslavsky, Maxim, Su, Yapeng, Guo, Jing, Sikora, Michael J., van Unen, Vincent, Christophersen, Asbjørn, Chiou, Shin-Heng, Chen, Liang, Li, Jiefu, Ji, Xuhuai, Wilhelmy, Julie, McSween, Alana M., Palanski, Brad A., Mallajosyula, Venkata Vamsee Aditya, Bracey, Nathan A., Dhondalay, Gopal Krishna R., Bhamidipati, Kartik, Pai, Joy, Kipp, Lucas B., Dunn, Jeffrey E., Hauser, Stephen L., Oksenberg, Jorge R., Satpathy, Ansuman T., Robinson, William H., Dekker, Cornelia L., Steinmetz, Lars M., Khosla, Chaitan, Utz, Paul J., Sollid, Ludvig M., Chien, Yueh-Hsiu, Heath, James R., Fernandez-Becker, Nielsen Q., Nadeau, Kari C., Saligrama, Naresha, Davis, Mark M.
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 15.04.2022; American Association for the Advancement of Science
• Subjects: Ablation; Animals; Antiviral drugs; Autoimmune Diseases; Autoimmunity; CD4 antigen; CD8 antigen; CD8-Positive T-Lymphocytes; Celiac disease; Control Groups; Coronaviruses; COVID-19; Cytolytic activity; Cytotoxicity; Depletion; Equivalence; Experimental allergic encephalomyelitis; Functionals; Gene sequencing; Gliadin; Glycoproteins; Humans; Immunoglobulin-like receptors; Immunoglobulins; Immunological tolerance; Immunology; In vitro methods and tests; Infections; Infectious diseases; Inflammation; Influenza; Killer cell immunoglobulin-like receptors; Leukocytes; Long COVID; Lymphocytes; Lymphocytes T; Major histocompatibility complex; Mice; Multiple sclerosis; Myelin; Negative feedback; Patients; Phenotypes; Receptors; Receptors, KIR; Respiratory diseases; Severe acute respiratory syndrome coronavirus 2; Signs and symptoms; T cell receptors; T-Lymphocytes, Regulatory; Toxicity; Transcription; Vasculitis; Viral diseases; Viral infections; Viruses

In this work, we find that CD8 + T cells expressing inhibitory killer cell immunoglobulin-like receptors (KIRs) are the human equivalent of Ly49 + CD8 + regulatory T cells in mice and are increased in the blood and inflamed tissues of patients with a variety of autoimmune diseases. Moreover, these C...