Inflammation-Related circRNA Polymorphism and Ischemic Stroke Prognosis

• Published in: Journal of molecular neuroscience Vol. 71; no. 10; pp. 2126 - 2133
• Main Authors: Liu, Xu, Wang, Qianwen, Zhao, Jingjing, Chang, Hongtao, Zhu, Ruixia
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2021; Springer Nature B.V
• Subjects: Alternative splicing; Biomarkers; Biomarkers - metabolism; Biomedical and Life Sciences; Biomedicine; Cell Biology; Exons; Female; Gene polymorphism; Genetic analysis; Health risks; Humans; Hypertension; Inflammation; Ischemia; Ischemic Stroke - genetics; Ischemic Stroke - pathology; Male; Middle Aged; Neurochemistry; Neurology; Neurosciences; Polymerase chain reaction; Polymorphism; Polymorphism, Single Nucleotide; Prognosis; Proteomics; Recovery; Regression models; Repressor Proteins - genetics; Risk analysis; Risk factors; RNA, Circular - genetics; SAP90-PSD95 Associated Proteins - genetics; Stat3 protein; STAT3 Transcription Factor - genetics; Stroke; Subgroups; TNF Receptor-Associated Factor 2 - genetics; TRAF2 protein; Transcription; Ubiquitin-Protein Ligases - genetics; Inflammation; Prognosis; Ischemic stroke; circRNA; Polymorphism

CircRNAs belong to a novel class of noncoding RNAs that are generated by exons of genes by alternative mRNA splicing and involved in pathophysiological processes of ischemic stroke by regulating neuro-inflammation. A total of 982 patients were enrolled in our study for stroke recovery analysis. The...