Genetic variants in N6-methyladenosine are associated with bladder cancer risk in the Chinese population

• Published in: Archives of toxicology Vol. 95; no. 1; pp. 299 - 309
• Main Authors: Liu, Hanting, Gu, Jingjing, Jin, Yu, Yuan, Qi, Ma, Gaoxiang, Du, Mulong, Ge, Yuqiu, Qin, Chao, Lv, Qiang, Fu, Guangbo, Wang, Meilin, Chu, Haiyan, Yuan, Lin, Zhang, Zhengdong
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.01.2021; Springer Nature B.V
• Subjects: Apoptosis; Biomedical and Life Sciences; Biomedicine; Bladder; Bladder cancer; Cancer; Cell proliferation; Environmental Health; Genetic diversity; Genetic variance; Genotoxicity and Carcinogenicity; Health risks; mRNA; N6-methyladenosine; Nucleotides; Occupational Medicine/Industrial Medicine; Pharmacology/Toxicology; Regression analysis; Regression models; Risk management; RNA-binding protein; Single-nucleotide polymorphism; Superoxide dismutase; Switches; Tumor suppressor genes; Molecular epidemiology; methyladenosine; Susceptibility; Bladder cancer; N; N6-methyladenosine

Recently N 6 -Methyladenosine (m 6 A) has been identified to guide the interaction of RNA-binding protein hnRNP C and their target RNAs, which is termed as m 6 A-switches. We systematically investigated the association between genetic variants in m 6 A-switches and bladder cancer risk. A two-stage c...