The NLRP3 Inflammasome and Its Role in Sepsis Development
The pathophysiology of sepsis is extremely complex. During this disease, the exacerbation of the inflammatory response causes oxidative stress, alterations in mitochondrial energy dynamics, and multiple organ failure. Some studies have highlighted the important role of the NLRP3 inflammasome in seps...
Saved in:
| Published in | Inflammation Vol. 43; no. 1; pp. 24 - 31 |
|---|---|
| Main Authors | , , , , |
| Format | Journal Article |
| Language | English |
| Published |
New York
Springer US
01.02.2020
Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
Cover
Loading…
| Abstract | The pathophysiology of sepsis is extremely complex. During this disease, the exacerbation of the inflammatory response causes oxidative stress, alterations in mitochondrial energy dynamics, and multiple organ failure. Some studies have highlighted the important role of the NLRP3 inflammasome in sepsis. This inflammasome is a macromolecular protein complex that finely regulates the activation of caspase-1 and the production and secretion of potent pro-inflammatory cytokines such as IL-1β and IL-18. In this review, we elucidate evidences to understand the connection between sepsis development and the NLRP3 inflammasome, the most widely investigated member of this class of receptor. |
|---|---|
| AbstractList | AbstractThe pathophysiology of sepsis is extremely complex. During this disease, the exacerbation of the inflammatory response causes oxidative stress, alterations in mitochondrial energy dynamics, and multiple organ failure. Some studies have highlighted the important role of the NLRP3 inflammasome in sepsis. This inflammasome is a macromolecular protein complex that finely regulates the activation of caspase-1 and the production and secretion of potent pro-inflammatory cytokines such as IL-1β and IL-18. In this review, we elucidate evidences to understand the connection between sepsis development and the NLRP3 inflammasome, the most widely investigated member of this class of receptor. The pathophysiology of sepsis is extremely complex. During this disease, the exacerbation of the inflammatory response causes oxidative stress, alterations in mitochondrial energy dynamics, and multiple organ failure. Some studies have highlighted the important role of the NLRP3 inflammasome in sepsis. This inflammasome is a macromolecular protein complex that finely regulates the activation of caspase-1 and the production and secretion of potent pro-inflammatory cytokines such as IL-1β and IL-18. In this review, we elucidate evidences to understand the connection between sepsis development and the NLRP3 inflammasome, the most widely investigated member of this class of receptor. The pathophysiology of sepsis is extremely complex. During this disease, the exacerbation of the inflammatory response causes oxidative stress, alterations in mitochondrial energy dynamics, and multiple organ failure. Some studies have highlighted the important role of the NLRP3 inflammasome in sepsis. This inflammasome is a macromolecular protein complex that finely regulates the activation of caspase-1 and the production and secretion of potent pro-inflammatory cytokines such as IL-1β and IL-18. In this review, we elucidate evidences to understand the connection between sepsis development and the NLRP3 inflammasome, the most widely investigated member of this class of receptor.The pathophysiology of sepsis is extremely complex. During this disease, the exacerbation of the inflammatory response causes oxidative stress, alterations in mitochondrial energy dynamics, and multiple organ failure. Some studies have highlighted the important role of the NLRP3 inflammasome in sepsis. This inflammasome is a macromolecular protein complex that finely regulates the activation of caspase-1 and the production and secretion of potent pro-inflammatory cytokines such as IL-1β and IL-18. In this review, we elucidate evidences to understand the connection between sepsis development and the NLRP3 inflammasome, the most widely investigated member of this class of receptor. |
| Author | Bonfante, Sandra Danielski, Lucinéia Gainski Barichello, Tatiana Giustina, Amanda Della Petronilho, Fabricia |
| Author_xml | – sequence: 1 givenname: Lucinéia Gainski surname: Danielski fullname: Danielski, Lucinéia Gainski organization: Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit, University of South Santa Catarina – sequence: 2 givenname: Amanda Della surname: Giustina fullname: Giustina, Amanda Della organization: Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit, University of South Santa Catarina – sequence: 3 givenname: Sandra surname: Bonfante fullname: Bonfante, Sandra organization: Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit, University of South Santa Catarina – sequence: 4 givenname: Tatiana surname: Barichello fullname: Barichello, Tatiana organization: Laboratory of Experimental Microbiology, Graduate Program in Health Sciences, Health Sciences Unit, University of Southern Santa Catarina, Center for Experimental Models in Psychiatry, Department of Psychiatry and Behavioral Sciences, Medical School, The University of Texas Health Science Center at Houston – sequence: 5 givenname: Fabricia orcidid: 0000-0003-3240-2808 surname: Petronilho fullname: Petronilho, Fabricia email: fabricia.petronilho@unisul.br organization: Laboratory of Neurobiology of Inflammatory and Metabolic Processes, Graduate Program in Health Sciences, Health Sciences Unit, University of South Santa Catarina |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31741197$$D View this record in MEDLINE/PubMed |
| BookMark | eNp9kMtKxDAUQIMoOj5-wIUU3Lip3ts0SbMUnwODyjiuQ6a91UqbjE1H8O-Njg9w4SJkc87Nzdlm6847Ymwf4RgB1ElAUIKngDoezPJUr7ERCsXTTCi5zkbAJaRca7XFtkN4BoBCF3yTbXFUOaJWI6ZnT5TcTKZ3PBm7urVdZ4PvKLGuSsZDSKa-paRxyT0tQhOSc3ql1i86csMu26htG2jv695hD5cXs7PrdHJ7NT47naQlV2JI5xI5AMeMClmrecahymUutLI55qIoSlCFqkq0VqCAXEP8Sl2XJKREqyrJd9jRau6i9y9LCoPpmlBS21pHfhlMxlFoqVGIiB7-QZ_9sndxu0gJRBAKPgYefFHLeUeVWfRNZ_s38x0lAtkKKHsfQk_1D4JgPsqbVXkTy5vP8kZHqfgjlc1gh8a7obdN-7_KV2qI77hH6n_X_sd6B4DLkpU |
| CitedBy_id | crossref_primary_10_1016_j_jmb_2021_167183 crossref_primary_10_1089_jir_2021_0241 crossref_primary_10_1002_jcp_31196 crossref_primary_10_1080_08923973_2023_2170241 crossref_primary_10_1002_btm2_10517 crossref_primary_10_1134_S002689332402002X crossref_primary_10_1016_j_cbi_2024_111030 crossref_primary_10_3389_fcell_2021_730621 crossref_primary_10_1016_j_hest_2022_10_005 crossref_primary_10_1016_j_bbrc_2021_11_017 crossref_primary_10_1002_iid3_1039 crossref_primary_10_1016_j_jneuroim_2024_578517 crossref_primary_10_3389_fimmu_2022_837180 crossref_primary_10_3389_fimmu_2023_1117548 crossref_primary_10_1016_j_bbadis_2024_167101 crossref_primary_10_2139_ssrn_4075839 crossref_primary_10_3390_diagnostics12010092 crossref_primary_10_3389_fimmu_2022_812164 crossref_primary_10_1016_j_semcdb_2022_11_006 crossref_primary_10_18632_aging_204628 crossref_primary_10_1007_s10753_021_01454_7 crossref_primary_10_1080_21655979_2022_2047406 crossref_primary_10_3389_fimmu_2020_591803 crossref_primary_10_3389_fimmu_2023_1105399 crossref_primary_10_1161_CIRCRESAHA_120_318075 crossref_primary_10_1002_ptr_8014 crossref_primary_10_1007_s11011_024_01425_5 crossref_primary_10_1016_j_jointm_2022_12_002 crossref_primary_10_1007_s10753_020_01232_x crossref_primary_10_1021_acs_jmedchem_3c00894 crossref_primary_10_1155_2022_1328729 crossref_primary_10_1097_MD_0000000000039185 crossref_primary_10_1016_j_intimp_2020_106872 crossref_primary_10_3389_fimmu_2021_733537 crossref_primary_10_3389_fmolb_2022_917818 crossref_primary_10_3389_fimmu_2020_594071 crossref_primary_10_1038_s41401_023_01212_5 crossref_primary_10_1016_j_phrs_2024_107223 crossref_primary_10_1007_s12011_024_04369_0 crossref_primary_10_3389_fimmu_2021_763831 crossref_primary_10_1007_s00018_021_03970_z crossref_primary_10_3389_fnut_2022_999998 crossref_primary_10_1016_j_intimp_2023_109819 crossref_primary_10_3390_jpm14060619 crossref_primary_10_1016_j_ejphar_2021_174644 crossref_primary_10_1016_j_intimp_2025_114088 crossref_primary_10_1038_s41418_022_00966_5 crossref_primary_10_1002_adbi_202300220 crossref_primary_10_1016_j_jep_2022_115205 crossref_primary_10_3390_ph14060588 crossref_primary_10_1016_j_isci_2024_111404 crossref_primary_10_3390_vaccines10101648 crossref_primary_10_1073_pnas_2210809119 crossref_primary_10_1016_j_lfs_2024_122611 crossref_primary_10_1186_s12964_023_01041_3 crossref_primary_10_1097_SHK_0000000000001624 crossref_primary_10_1007_s11033_022_07377_2 crossref_primary_10_3390_ijms221910330 crossref_primary_10_3390_life11030182 crossref_primary_10_1007_s10787_023_01378_8 crossref_primary_10_1016_j_labinv_2022_100028 crossref_primary_10_1016_j_phymed_2024_155345 crossref_primary_10_1021_acs_jmedchem_4c02648 crossref_primary_10_3389_fcimb_2024_1532417 crossref_primary_10_1155_2021_6687555 crossref_primary_10_4239_wjd_v14_i5_460 crossref_primary_10_1007_s12035_023_03870_2 crossref_primary_10_3389_fphar_2025_1430536 crossref_primary_10_1111_ctr_14888 crossref_primary_10_3389_fendo_2023_1124334 crossref_primary_10_1038_s41401_021_00739_9 crossref_primary_10_3389_fimmu_2023_1205132 crossref_primary_10_1016_j_jpha_2024_101069 crossref_primary_10_1016_j_compbiomed_2024_108222 crossref_primary_10_1097_MOL_0000000000000782 crossref_primary_10_1183_23120541_00572_2023 crossref_primary_10_3389_fimmu_2023_1114917 crossref_primary_10_1097_SHK_0000000000002262 crossref_primary_10_3389_fimmu_2022_1035709 crossref_primary_10_1016_j_jointm_2024_01_001 crossref_primary_10_1016_j_lfs_2024_122604 crossref_primary_10_1016_j_intimp_2025_114222 crossref_primary_10_3892_ijmm_2023_5337 crossref_primary_10_1177_07487304221092727 crossref_primary_10_1007_s10157_023_02448_5 crossref_primary_10_1021_acsinfecdis_1c00270 crossref_primary_10_3389_fphar_2021_652860 crossref_primary_10_1016_j_biopha_2022_113804 crossref_primary_10_3233_ISB_200474 crossref_primary_10_1016_j_bcp_2023_115894 crossref_primary_10_1016_j_molimm_2021_10_014 crossref_primary_10_1016_j_mvr_2023_104491 crossref_primary_10_1097_SHK_0000000000002140 crossref_primary_10_18632_aging_202191 crossref_primary_10_1084_jem_20202413 crossref_primary_10_3389_fimmu_2022_788556 crossref_primary_10_3389_fimmu_2020_581758 crossref_primary_10_1016_j_lfs_2020_118617 crossref_primary_10_1039_D3NR05570A crossref_primary_10_1080_21505594_2025_2451163 crossref_primary_10_1186_s13578_024_01239_z crossref_primary_10_3390_molecules28227527 crossref_primary_10_1002_ptr_7917 crossref_primary_10_1172_jci_insight_181686 crossref_primary_10_3892_mmr_2021_12369 crossref_primary_10_1111_jpi_12845 crossref_primary_10_2147_JIR_S447811 crossref_primary_10_1016_j_peptides_2021_170612 crossref_primary_10_1016_j_intimp_2023_110275 crossref_primary_10_1016_j_heliyon_2023_e23599 crossref_primary_10_1155_2022_1269747 crossref_primary_10_1007_s00011_024_01922_4 crossref_primary_10_1007_s12035_022_02823_5 crossref_primary_10_2139_ssrn_4012963 crossref_primary_10_1016_j_biopha_2024_116929 crossref_primary_10_1016_j_intimp_2021_107388 crossref_primary_10_3390_biom10010093 crossref_primary_10_1016_j_celrep_2022_111941 crossref_primary_10_1038_s41390_024_03023_8 crossref_primary_10_1096_fj_202000665RR crossref_primary_10_3389_fimmu_2022_1019365 crossref_primary_10_1016_j_cellimm_2024_104888 crossref_primary_10_1016_j_intimp_2024_112822 crossref_primary_10_1038_s41598_021_92547_8 crossref_primary_10_3390_jcm10081693 crossref_primary_10_1080_14728222_2023_2257888 crossref_primary_10_1186_s12974_022_02682_w crossref_primary_10_1016_j_phymed_2022_154427 crossref_primary_10_3389_fnut_2022_1037861 crossref_primary_10_1042_CS20220549 crossref_primary_10_1016_j_lfs_2020_118166 crossref_primary_10_1016_j_molimm_2024_12_007 crossref_primary_10_3390_ijms22042108 crossref_primary_10_1186_s12879_024_09752_9 crossref_primary_10_1016_j_ejphar_2024_176834 crossref_primary_10_3389_fmolb_2024_1425143 crossref_primary_10_1021_acs_jmedchem_4c01341 crossref_primary_10_1097_JS9_0000000000000789 crossref_primary_10_1093_jleuko_qiad161 crossref_primary_10_2139_ssrn_3946892 crossref_primary_10_3389_fimmu_2023_1188482 crossref_primary_10_1016_j_jep_2023_116615 crossref_primary_10_1016_j_bcp_2023_115638 crossref_primary_10_1371_journal_pone_0265758 crossref_primary_10_1038_s42003_022_03868_x crossref_primary_10_3390_ijms21228437 crossref_primary_10_1016_j_lfs_2023_122353 crossref_primary_10_1016_j_intimp_2023_109747 crossref_primary_10_1016_j_intimp_2023_110292 crossref_primary_10_3389_fimmu_2021_641750 crossref_primary_10_1016_j_biopha_2024_116633 crossref_primary_10_1016_j_ejphar_2021_174438 crossref_primary_10_1007_s12035_020_02089_9 crossref_primary_10_1155_2021_6370911 crossref_primary_10_1089_jir_2022_0061 crossref_primary_10_1016_j_intimp_2023_111022 crossref_primary_10_1016_j_heliyon_2024_e31007 crossref_primary_10_1016_j_trim_2024_102072 crossref_primary_10_1007_s12035_021_02445_3 crossref_primary_10_3389_fimmu_2024_1378506 crossref_primary_10_3389_fmed_2021_711397 crossref_primary_10_3389_fimmu_2024_1362727 crossref_primary_10_1016_j_ejmech_2023_115696 crossref_primary_10_1111_cpr_13470 crossref_primary_10_1016_j_phrs_2023_107016 crossref_primary_10_1007_s00281_022_00921_z |
| Cites_doi | 10.1089/sur.2017.298 10.14814/phy2.14073 10.1097/CCM.0b013e3181760c4b 10.1074/jbc.M109.014266 10.1371/journal.pone.0107639 10.1038/nrd.2018.97 10.1016/j.it.2018.01.009 10.1016/j.molimm.2018.09.010 10.1007/s10753-019-00990-7 10.1016/j.cpem.2014.04.007 10.1038/cr.2013.6 10.1038/ni.2215.Activation 10.1038/nature08938 10.3390/ijms160920595 10.1016/j.cardfail.2015.01.002 10.1007/s10753-018-0894-4 10.1111/jpi.12410 10.1016/j.cmet.2017.03.007 10.1016/j.intimp.2014.02.017 10.1080/08923973.2017.1355377 10.1177/09680519010070040901 10.1016/j.coi.2017.10.011 10.1016/j.jep.2015.02.056 10.1007/s12035-016-0356-7 10.1371/journal.pone.0120700 10.3389/fphar.2015.00262 10.1038/srep31649 10.1016/j.biopha.2017.05.126 10.3390/vaccines5040034 10.3389/fncel.2017.00063 10.1002/eji.201344063 10.1111/imm.12450 10.2147/JIR.S178084 10.1016/j.ccc.2017.08.002 10.1038/ni.1980.Autophagy 10.1371/journal.pone.0107072 10.1016/j.molimm.2017.02.013 10.1155/2016/1045657 10.1016/j.imlet.2016.09.009 10.1016/j.tibs.2016.09.002 10.1080/15548627.2016.1183081 10.1111/imm.12787 10.1016/j.imbio.2013.11.003 10.1056/NEJMra021333 10.1152/ajpcell.00298.2015 10.4049/jimmunol.1601745 10.1073/pnas.1317400111 10.1016/j.coi.2018.03.010 10.1111/cei.12457 10.1038/srep33201 10.1186/s13017-018-0165-6 10.1073/pnas.1117765109 10.5483/BMBRep.2016.49.10.115 10.1016/j.coi.2015.01.007 10.1164/rccm.201604-0892OC 10.1159/000341681 10.1097/00062752-200201000-00002 10.5551/jat.RV17001 10.1111/nyas.12458.Mechanism 10.3389/fimmu.2017.00036 10.1172/JCI78253.interact 10.18632/oncotarget.13010 10.2174/1389450117666160527143143 10.1038/s41467-017-00213-3 |
| ContentType | Journal Article |
| Copyright | Springer Science+Business Media, LLC, part of Springer Nature 2019 Inflammation is a copyright of Springer, (2019). All Rights Reserved. |
| Copyright_xml | – notice: Springer Science+Business Media, LLC, part of Springer Nature 2019 – notice: Inflammation is a copyright of Springer, (2019). All Rights Reserved. |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 3V. 7T5 7TO 7U9 7X7 7XB 88E 8AO 8FI 8FJ 8FK ABUWG AFKRA BENPR CCPQU FYUFA GHDGH H94 K9. M0S M1P PHGZM PHGZT PJZUB PKEHL PPXIY PQEST PQQKQ PQUKI PRINS 7X8 |
| DOI | 10.1007/s10753-019-01124-9 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed ProQuest Central (Corporate) Immunology Abstracts Oncogenes and Growth Factors Abstracts Virology and AIDS Abstracts Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) ProQuest Central ProQuest Central UK/Ireland ProQuest Central ProQuest One Health Research Premium Collection Health Research Premium Collection (Alumni) AIDS and Cancer Research Abstracts ProQuest Health & Medical Complete (Alumni) ProQuest Health & Medical Collection Medical Database ProQuest Central Premium ProQuest One Academic (New) ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Academic ProQuest One Academic UKI Edition ProQuest Central China MEDLINE - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Oncogenes and Growth Factors Abstracts ProQuest One Academic Middle East (New) ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Pharma Collection ProQuest Central China ProQuest Central Health Research Premium Collection Health and Medicine Complete (Alumni Edition) Health & Medical Research Collection AIDS and Cancer Research Abstracts ProQuest Central (New) ProQuest Medical Library (Alumni) Virology and AIDS Abstracts ProQuest One Academic Eastern Edition ProQuest Hospital Collection Health Research Premium Collection (Alumni) ProQuest Hospital Collection (Alumni) ProQuest Health & Medical Complete ProQuest Medical Library ProQuest One Academic UKI Edition Immunology Abstracts ProQuest One Academic ProQuest One Academic (New) ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Oncogenes and Growth Factors Abstracts MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: EIF name: MEDLINE url: https://proxy.k.utb.cz/login?url=https://www.webofscience.com/wos/medline/basic-search sourceTypes: Index Database – sequence: 3 dbid: BENPR name: ProQuest Central url: https://www.proquest.com/central sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine |
| EISSN | 1573-2576 |
| EndPage | 31 |
| ExternalDocumentID | 31741197 10_1007_s10753_019_01124_9 |
| Genre | Journal Article Review |
| GroupedDBID | --- -53 -5E -5G -BR -EM -Y2 -~C .86 .GJ .VR 06C 06D 0R~ 0VY 1N0 1SB 2.D 203 28- 29I 29~ 2J2 2JN 2JY 2KG 2KM 2LR 2P1 2VQ 2~H 30V 3SX 3V. 4.4 406 408 409 40D 40E 53G 5GY 5QI 5RE 5VS 67Z 6NX 78A 7X7 88E 8AO 8FI 8FJ 8TC 8UJ 95- 95. 95~ 96X AAAVM AABHQ AACDK AAHNG AAIAL AAJBT AAJKR AAJSJ AANXM AANZL AARHV AARTL AASML AATNV AATVU AAUYE AAWCG AAYIU AAYQN AAYTO AAYZH ABAKF ABBBX ABBXA ABDZT ABECU ABFTV ABHLI ABHQN ABJNI ABJOX ABKCH ABKTR ABMNI ABMQK ABNWP ABPLI ABQBU ABQSL ABSXP ABTEG ABTKH ABTMW ABULA ABUWG ABWNU ABXPI ACAOD ACGFS ACHSB ACHXU ACKNC ACMDZ ACMLO ACOKC ACOMO ACPIV ACPRK ACUDM ACULB ACZOJ ADBBV ADHHG ADHIR ADIMF ADINQ ADKNI ADKPE ADRFC ADTPH ADURQ ADYFF ADZKW AEBTG AEFIE AEFQL AEGAL AEGNC AEJHL AEJRE AEKMD AEMSY AENEX AEOHA AEPYU AESKC AETLH AEVLU AEXYK AFBBN AFEXP AFFNX AFKRA AFLOW AFQWF AFWTZ AFZKB AGAYW AGDGC AGGDS AGJBK AGMZJ AGQEE AGQMX AGRTI AGWIL AGWZB AGYKE AHAVH AHBYD AHKAY AHMBA AHSBF AHYZX AIAKS AIGIU AIIXL AILAN AITGF AJBLW AJRNO AJZVZ AKMHD ALIPV ALMA_UNASSIGNED_HOLDINGS ALWAN AMKLP AMXSW AMYLF AMYQR AOCGG ARMRJ ASPBG AVWKF AXYYD AZFZN B-. BA0 BBWZM BDATZ BENPR BGNMA BPHCQ BSONS BVXVI C6C CAG CCPQU COF CS3 CSCUP DDRTE DL5 DNIVK DPUIP DU5 EBD EBLON EBS EIOEI EJD EMB EMOBN EN4 EPAXT ESBYG F5P FEDTE FERAY FFXSO FIGPU FINBP FNLPD FRRFC FSGXE FWDCC FYUFA G-Y G-Z GGCAI GGRSB GJIRD GNWQR GQ6 GQ7 GQ8 GRRUI GXS H13 HF~ HG5 HG6 HMCUK HMJXF HQYDN HRMNR HVGLF HZ~ I09 IHE IJ- IKXTQ ITM IWAJR IXC IZIGR IZQ I~X I~Z J-C J0Z JBSCW JCJTX JZLTJ KDC KOV KOW KPH LAK LLZTM M1P M4Y MA- N2Q NB0 NDZJH NPVJJ NQJWS NU0 O9- O93 O9G O9I O9J OAM OVD P19 P2P P9S PF0 PQQKQ PROAC PSQYO PT4 PT5 Q2X QOK QOR QOS R4E R89 R9I RHV RNI ROL RPX RRX RSV RZC RZE RZK S16 S1Z S26 S27 S28 S37 S3B SAP SBY SCLPG SDE SDH SDM SHX SISQX SJYHP SMD SNE SNPRN SNX SOHCF SOJ SPISZ SRMVM SSLCW SSXJD STPWE SV3 SZ9 SZN T13 T16 TEORI TSG TSK TSV TT1 TUC U2A U9L UG4 UKHRP UOJIU UTJUX UZXMN VC2 VFIZW W23 W48 WJK WK6 WK8 Y6R YLTOR Z45 Z7U Z83 Z87 Z8O Z8W Z91 ZGI ZMTXR ZOVNA ~A9 ~EX AAPKM AAYXX ABBRH ABDBE ABEEZ ABFSG ACSTC ADHKG AEZWR AFDZB AFGXO AFHIU AFOHR AGQPQ AHPBZ AHWEU AIXLP ATHPR AYFIA CITATION PHGZM PHGZT CGR CUY CVF ECM EIF NPM 7T5 7TO 7U9 7XB 8FK H94 K9. PJZUB PKEHL PPXIY PQEST PQUKI PRINS 7X8 |
| ID | FETCH-LOGICAL-c375t-b61300312e86f7b230d464597a414588c0787dc1aa5150490011ffce5661a7d63 |
| IEDL.DBID | 7X7 |
| ISSN | 0360-3997 1573-2576 |
| IngestDate | Fri Jul 11 09:31:49 EDT 2025 Sat Jul 26 00:47:02 EDT 2025 Thu Apr 03 07:11:10 EDT 2025 Tue Jul 01 01:49:24 EDT 2025 Thu Apr 24 22:59:57 EDT 2025 Fri Feb 21 02:34:44 EST 2025 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 1 |
| Keywords | NLRP3 inflammasome sepsis organ failure |
| Language | English |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c375t-b61300312e86f7b230d464597a414588c0787dc1aa5150490011ffce5661a7d63 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Review-3 content type line 23 |
| ORCID | 0000-0003-3240-2808 |
| PMID | 31741197 |
| PQID | 2351105706 |
| PQPubID | 37566 |
| PageCount | 8 |
| ParticipantIDs | proquest_miscellaneous_2315969155 proquest_journals_2351105706 pubmed_primary_31741197 crossref_primary_10_1007_s10753_019_01124_9 crossref_citationtrail_10_1007_s10753_019_01124_9 springer_journals_10_1007_s10753_019_01124_9 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 20200200 2020-02-00 2020-Feb 20200201 |
| PublicationDateYYYYMMDD | 2020-02-01 |
| PublicationDate_xml | – month: 2 year: 2020 text: 20200200 |
| PublicationDecade | 2020 |
| PublicationPlace | New York |
| PublicationPlace_xml | – name: New York – name: United States |
| PublicationTitle | Inflammation |
| PublicationTitleAbbrev | Inflammation |
| PublicationTitleAlternate | Inflammation |
| PublicationYear | 2020 |
| Publisher | Springer US Springer Nature B.V |
| Publisher_xml | – name: Springer US – name: Springer Nature B.V |
| References | Murakami, Ockinger, Yu, Byles, McColl, Hofer, Horng (CR44) 2012; 109 Beutler (CR7) 2002; 9 Yang, Zhao, Shao (CR26) 2015; 32 Mao, Chen, Chen, Ma, Wang, Huang, He, Zeng, Hu, Sun, Li, Wu, Wang, Strober, Chen, Meng, Sun (CR35) 2013; 23 Vozza, Parisi, De Leonardis, Lasorsa, Castegna (CR41) 2014; 111 Harris, Lang, Thomas, Sukkar, Nabar, Kehrl (CR43) 2017; 86 Sartelli, Kluger, Ansaloni, Hardcastle, Rello, Watkins, Bassetti (CR2) 2018; 13 Kim, Yoon, Ryu (CR30) 2016; 49 Luo, Jiang, Kang, Fei, Meng, Nan, Pan, Zhao, Zhao (CR61) 2014; 20 Ziesmann, Marshall (CR1) 2018; 19 Mangan, Olhava, Roush, Seidel, Glick, Latz (CR10) 2018; 17 Wu, Ren, Zhou, Ding, Chen, Wang, Gu, Wu, Liu, Hu, Li (CR54) 2015; 179 Zhao, Zhang, Sui, Zhu, Zeng (CR58) 2016; 6 Beutler, Du, Poltorak (CR6) 2001; 7 Danielski, Giustina, Badawy, Barichello, Quevedo, Dal-Pizzol, Petronilho (CR14) 2017; 55 Han, Shim, Shim, Kim, Shin, Kwak, Koppula, Kim, Kang, Lee (CR37) 2015; 166 Kuzmich, Sivak, Chubarev, Porozov, Savateeva-Lyubimova, Peri (CR5) 2017; 5 Conway-Morris, Wilson, Shankar-Hari (CR27) 2018; 34 Kumar (CR8) 2018; 11 Hotchkiss, Karl (CR3) 2003; 348 Yi (CR25) 2017; 152 Sui, Xie, Yi, Gupta, Yu, Li, Wang, Wang, Deng (CR64) 2016; 2016 Place, Kanneganti (CR9) 2018; 50 Hafner-Bratkovič, Pelegrín (CR19) 2018; 52 Ahn, Kim, Jeung, Lee (CR36) 2014; 219 Zhang, Wang, Gurley, Zhou (CR39) 2014; 9 CR46 CR45 CR42 Chen, Xu, Liang, Wei, Luo, Chen, Yan (CR53) 2016 Costa, Ana Paula (CR40) 2008; 36 Miao, Jiang, He, Li, Liu, Cao, Zhi-bing, Gong, Liu, Cheng (CR56) 2016; 179 Song, Pei, Yao, Wu, Shang (CR11) 2017; 11 Zhang, Xu, Kao, Mele, Kvietys, Martin (CR49) 2014 Bauer, Duewell, Lehr, Endres, Schnurr (CR12) 2012; 30 Liu, Zhang, Hu, Zhou, Yang (CR21) 2018; 103 Cornelius, Baik, Travis, White, Young, Austin Pierce, Shields, Poudel, Williams (CR52) 2019; 7 Shao, Xu, Han, Ding Feng, Liu (CR20) 2015; 6 Hao, Cao, Jiang, Che, Zhang, Takahashi, Wang, Gonzalez (CR55) 2017; 25 Babelova, Moreth, Tsalastra-Greul, Zeng-Brouwers, Eickelberg, Young, Bruckner, Pfeilschifter, Schaefer, Gröne, Schaefer (CR28) 2009; 284 Zhang, Liu, Sui, Cai, Liu, Zhu, Yin (CR51) 2015; 21 CR17 Gong, Yang, Jin, Jiang, Zhou (CR23) 2018; 39 Katsnelson, Lozada-Soto, Russo, Miller, Dubyak (CR24) 2016; 311 He, Hara, Núñez (CR18) 2016; 41 Karasawa, Takahashi (CR15) 2017; 24 Rahim, Djerdjouri, Sayed, Fernández-Ortiz, Fernández-Gil, Hidalgo-Gutiérrez, López, Escames, Reiter, Acuña-Castroviejo (CR50) 2017; 63 Patel (CR16) 2017; 92 Lee, Hsu, Li, Chen, Liu (CR57) 2015; 10 Kim, Bae, Ryu, Kwon, Ji-Hwan, Kwon, Moon (CR31) 2016; 12 Censoplano, Epting, Coates (CR4) 2014; 15 Lee, Nakahira, Dalli, Siempos, Norris, Colas, Moon (CR33) 2017; 196 Kumar, Gupta, Anilkumar, Fatima, Karnati, Reddy, Giri, Reddanna (CR38) 2016; 6 Wang, Huang, Li, Chang, Wu, Lin (CR59) 2015 Fu, Wu, Zhou, Ji, Mao, Li, Zong, Zhou, Yang (CR65) 2019; 42 Duewell, Kono, Rayner, Sirois, Vladimer, Bauernfeind, Abela (CR13) 2010; 464 Xu, Wang, Wen, Sang, Wang, Zeng (CR62) 2017; 39 Wang, Liu, Zheng, Liu, Xu, Liu, Gao, Bai, Li (CR63) 2019; 42 CR22 Gentile, Cuenca, Cuenca, Nacionales, Ungaro, Efron, Moldawer, Larson (CR34) 2015; 145 CR60 Chaly, Fu, Marinov, Hostager, Yan, Campfield, Kellum, Bushnell, Wang, Vockley, Hirsch (CR29) 2014; 44 Jin, Batra, Jeyaseelan (CR32) 2017; 198 Nakahira, Haspel, Rathinam, Lee, Lam, Englert, Rabinovitch (CR48) 2011; 12 Shi, Shenderov, Huang, Kabat, Abu-asab, Fitzgerald, Sher, Kehrl (CR47) 2014; 13 LG Danielski (1124_CR14) 2017; 55 J-w Han (1124_CR37) 2015; 166 P Duewell (1124_CR13) 2010; 464 H Hao (1124_CR55) 2017; 25 Y He (1124_CR18) 2016; 41 N Kumar (1124_CR38) 2016; 6 M-J Kim (1124_CR31) 2016; 12 L Jin (1124_CR32) 2017; 198 Y Wu (1124_CR54) 2015; 179 DE Place (1124_CR9) 2018; 50 M-J Kim (1124_CR30) 2016; 49 C Bauer (1124_CR12) 2012; 30 C-s Shi (1124_CR47) 2014; 13 Y-c Wang (1124_CR63) 2019; 42 C-m Miao (1124_CR56) 2016; 179 T. Murakami (1124_CR44) 2012; 109 A Vozza (1124_CR41) 2014; 111 P Wang (1124_CR59) 2015 W Zhang (1124_CR49) 2014 T Karasawa (1124_CR15) 2017; 24 1124_CR42 1124_CR45 1124_CR46 N Kuzmich (1124_CR5) 2017; 5 B Beutler (1124_CR6) 2001; 7 F Xu (1124_CR62) 2017; 39 P Costa (1124_CR40) 2008; 36 RS Hotchkiss (1124_CR3) 2003; 348 James Harris (1124_CR43) 2017; 86 A Conway-Morris (1124_CR27) 2018; 34 Y-p Luo (1124_CR61) 2014; 20 J Yang (1124_CR26) 2015; 32 Andrea Babelova (1124_CR28) 2009; 284 Markus T. Ziesmann (1124_CR1) 2018; 19 H Ahn (1124_CR36) 2014; 219 S Lee (1124_CR33) 2017; 196 BZ Shao (1124_CR20) 2015; 6 N Censoplano (1124_CR4) 2014; 15 Y-S Yi (1124_CR25) 2017; 152 Xiaoxuan Zhang (1124_CR39) 2014; 9 S Patel (1124_CR16) 2017; 92 Yury Chaly (1124_CR29) 2014; 44 1124_CR17 I Rahim (1124_CR50) 2017; 63 Q Liu (1124_CR21) 2018; 103 Denise C. Cornelius (1124_CR52) 2019; 7 1124_CR60 L Song (1124_CR11) 2017; 11 Kairui Mao (1124_CR35) 2013; 23 BO Zhang (1124_CR51) 2015; 21 1124_CR22 W-y Zhao (1124_CR58) 2016; 6 MA Katsnelson (1124_CR24) 2016; 311 V Kumar (1124_CR8) 2018; 11 I Hafner-Bratkovič (1124_CR19) 2018; 52 M Sartelli (1124_CR2) 2018; 13 K Nakahira (1124_CR48) 2011; 12 T Gong (1124_CR23) 2018; 39 Shih-Chieh Lee (1124_CR57) 2015; 10 Q Fu (1124_CR65) 2019; 42 MSJ Mangan (1124_CR10) 2018; 17 B Beutler (1124_CR7) 2002; 9 Lori F. Gentile (1124_CR34) 2015; 145 D-m Sui (1124_CR64) 2016; 2016 Y-l Chen (1124_CR53) 2016 |
| References_xml | – ident: CR45 – ident: CR22 – volume: 19 start-page: 184 issue: 2 year: 2018 end-page: 190 ident: CR1 article-title: Multiple Organ Dysfunction: The Defining Syndrome of Sepsis publication-title: Surgical Infections doi: 10.1089/sur.2017.298 – volume: 7 start-page: e14073 issue: 9 year: 2019 ident: CR52 article-title: NLRP 3 inflammasome activation in platelets in response to sepsis publication-title: Physiological Reports doi: 10.14814/phy2.14073 – volume: 36 start-page: 1925 year: 2008 end-page: 1932 ident: CR40 article-title: A Santiago, Rodrigo T Amâncio, Antonio Galina, Marcus F Oliveira, and Fernando A Bozza publication-title: Sepsis induces brain mitochondrial dysfunction doi: 10.1097/CCM.0b013e3181760c4b – volume: 284 start-page: 24035 issue: 36 year: 2009 end-page: 24048 ident: CR28 article-title: Biglycan, a Danger Signal That Activates the NLRP3 Inflammasome via Toll-like and P2X Receptors publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M109.014266 – year: 2014 ident: CR49 publication-title: Cardiac fibroblasts contribute to myocardial dysfunction in mice with sepsis : the role of NLRP3 inflammasome activation doi: 10.1371/journal.pone.0107639 – volume: 17 start-page: 588 year: 2018 end-page: 606 ident: CR10 article-title: Targeting the NLRP3 inflammasome in inflammatory diseases publication-title: Nature Reviews Drug Discovery doi: 10.1038/nrd.2018.97 – volume: 39 start-page: 393 year: 2018 end-page: 406 ident: CR23 article-title: Orchestration of NLRP3 inflammasome activation by ion fluxes publication-title: Trends in Immunology doi: 10.1016/j.it.2018.01.009 – volume: 103 start-page: 115 year: 2018 end-page: 124 ident: CR21 article-title: The role of mitochondria in NLRP3 inflammasome activation publication-title: Molecular Immunology doi: 10.1016/j.molimm.2018.09.010 – volume: 42 start-page: 1301 year: 2019 end-page: 1310 ident: CR63 article-title: Dihydromyricetin alleviates sepsis-induced acute lung injury through inhibiting NLRP3 inflammasome-dependent pyroptosis in mice model publication-title: Inflammation doi: 10.1007/s10753-019-00990-7 – volume: 15 start-page: 169 year: 2014 end-page: 176 ident: CR4 article-title: The role of the innate immune system in sepsis publication-title: Clinical Pediatric Emergency Medicine doi: 10.1016/j.cpem.2014.04.007 – volume: 23 start-page: 201 issue: 2 year: 2013 end-page: 212 ident: CR35 article-title: Nitric oxide suppresses NLRP3 inflammasome activation and protects against LPS-induced septic shock publication-title: Cell Research doi: 10.1038/cr.2013.6 – volume: 13 start-page: 255 year: 2014 end-page: 263 ident: CR47 article-title: Activation of autophagy by inflammatory signals limits IL-1β production by targeting ubiquitinated inflammasomes for destruction publication-title: Nature Immunology doi: 10.1038/ni.2215.Activation – volume: 464 start-page: 1357 year: 2010 end-page: 1361 ident: CR13 article-title: NLRP3 inflammasomes are required for atherogenesis and activated by cholesterol crystals publication-title: Nature doi: 10.1038/nature08938 – start-page: 20595 year: 2015 end-page: 20608 ident: CR59 publication-title: Exogenous carbon monoxide decreases sepsis-induced acute kidney injury and inhibits NLRP3 inflammasome activation in rats doi: 10.3390/ijms160920595 – volume: 21 start-page: 426 year: 2015 end-page: 433 ident: CR51 article-title: Cortistatin inhibits NLRP3 inflammasome activation of cardiac fibroblasts during sepsis publication-title: Journal of Cardiac Failure doi: 10.1016/j.cardfail.2015.01.002 – ident: CR42 – volume: 42 start-page: 306 year: 2019 end-page: 318 ident: CR65 article-title: NLRP3/Caspase-1 pathway-induced pyroptosis mediated cognitive deficits in a mouse model of sepsis-associated encephalopathy publication-title: Inflammation doi: 10.1007/s10753-018-0894-4 – volume: 63 start-page: e12410 year: 2017 ident: CR50 article-title: Melatonin administration to wild-type mice and nontreated NLRP3 mutant mice share similar inhibition of the inflammatory response during sepsis publication-title: Journal of Pineal Research doi: 10.1111/jpi.12410 – volume: 25 start-page: 856 year: 2017 end-page: 867 ident: CR55 article-title: Farnesoid X Receptor regulation of the NLRP3 inflammasome underlies cholestasis-associated sepsis publication-title: Cell Metabolism doi: 10.1016/j.cmet.2017.03.007 – ident: CR46 – volume: 20 start-page: 24 year: 2014 end-page: 32 ident: CR61 article-title: International Immunopharmacology Hemin inhibits NLRP3 inflammasome activation in sepsis-induced acute lung injury , involving heme oxygenase-1 publication-title: International Immunopharmacology doi: 10.1016/j.intimp.2014.02.017 – volume: 39 start-page: 296 year: 2017 end-page: 304 ident: CR62 article-title: Inhibition of NLRP3 inflammasome: a new protective mechanism of cinnamaldehyde in endotoxin poisoning of mice publication-title: Immunopharmacology and Immunotoxicology doi: 10.1080/08923973.2017.1355377 – volume: 7 start-page: 277 year: 2001 end-page: 280 ident: CR6 article-title: Identification of Toll-like receptor 4 (TLR4) as the sole conduit for LPS signal transduction: genetic and evolutionary studies publication-title: Journal of Endotoxin Research doi: 10.1177/09680519010070040901 – volume: 50 start-page: 32 year: 2018 end-page: 38 ident: CR9 article-title: Recent advances in inflammasome biology publication-title: Current Opinion in Immunology doi: 10.1016/j.coi.2017.10.011 – volume: 166 start-page: 1 year: 2015 end-page: 4 ident: CR37 article-title: Syneilesis palmata (Thunb.) Maxim. extract attenuates inflammatory responses via the regulation of TRIF-dependent signaling and inflammasome activation publication-title: Journal of Ethnopharmacology doi: 10.1016/j.jep.2015.02.056 – volume: 55 start-page: 1 year: 2017 end-page: 9 ident: CR14 article-title: Brain barrier breakdown as a cause and consequence of neuroinflammation in sepsis publication-title: Molecular Neurobiology. Molecular Neurobiology doi: 10.1007/s12035-016-0356-7 – volume: 10 start-page: e0120700 issue: 3 year: 2015 ident: CR57 article-title: Protective Effect of Leaf Essential Oil from Cinnamomum osmophloeum Kanehira on Endotoxin-Induced Intestinal Injury in Mice Associated with Suppressed Local Expression of Molecules in the Signaling Pathways of TLR4 and NLRP3 publication-title: PLOS ONE doi: 10.1371/journal.pone.0120700 – volume: 6 start-page: 1 year: 2015 end-page: 9 ident: CR20 article-title: NLRP3 inflammasome and its inhibitors: A review publication-title: Frontiers in Pharmacology doi: 10.3389/fphar.2015.00262 – volume: 6 start-page: 31649 year: 2016 ident: CR38 article-title: 15-Lipoxygenase metabolites of α-linolenic acid, [13-(S)-HPOTrE and 13-(S)-HOTrE], mediate anti-inflammatory effects by inactivating NLRP3 inflammasome publication-title: Scientific Reports doi: 10.1038/srep31649 – ident: CR60 – volume: 92 start-page: 819 year: 2017 end-page: 825 ident: CR16 article-title: Inflammasomes, the cardinal pathology mediators are activated by pathogens, allergens and mutagens: A critical review with focus on NLRP3 publication-title: Biomedicine and Pharmacotherapy doi: 10.1016/j.biopha.2017.05.126 – volume: 5 start-page: 34 year: 2017 ident: CR5 article-title: TLR4 signaling pathway modulators as potential therapeutics in inflammation and sepsis publication-title: Vaccines doi: 10.3390/vaccines5040034 – volume: 11 start-page: 1 year: 2017 end-page: 17 ident: CR11 article-title: NLRP3 inflammasome in neurological diseases, from functions to therapies publication-title: Frontiers in Cellular Neuroscience doi: 10.3389/fncel.2017.00063 – volume: 44 start-page: 1467 issue: 5 year: 2014 end-page: 1479 ident: CR29 article-title: Follistatin-like protein 1 enhances NLRP3 inflammasome-mediated IL-1β secretion from monocytes and macrophages publication-title: European Journal of Immunology doi: 10.1002/eji.201344063 – volume: 145 start-page: 300 issue: 2 year: 2015 end-page: 311 ident: CR34 article-title: Improved emergency myelopoiesis and survival in neonatal sepsis by caspase-1/11 ablation publication-title: Immunology doi: 10.1111/imm.12450 – volume: 11 start-page: 477 year: 2018 end-page: 502 ident: CR8 article-title: Inflammasomes: Pandora’s box for sepsis publication-title: Journal of Inflammation Research doi: 10.2147/JIR.S178084 – volume: 34 start-page: 29 year: 2018 end-page: 42 ident: CR27 article-title: Immune activation in sepsis publication-title: Critical Care Clinics doi: 10.1016/j.ccc.2017.08.002 – volume: 12 start-page: 222 year: 2011 end-page: 230 ident: CR48 article-title: Autophagy proteins regulate innate immune response by inhibiting NALP3 inflammasome-mediated mitochondrial DNA release publication-title: Nature Immunology doi: 10.1038/ni.1980.Autophagy – volume: 9 start-page: e107072 issue: 9 year: 2014 ident: CR39 article-title: Flavonoid Apigenin Inhibits Lipopolysaccharide-Induced Inflammatory Response through Multiple Mechanisms in Macrophages publication-title: PLoS ONE doi: 10.1371/journal.pone.0107072 – volume: 86 start-page: 10 year: 2017 end-page: 15 ident: CR43 article-title: Autophagy and inflammasomes publication-title: Molecular Immunology doi: 10.1016/j.molimm.2017.02.013 – volume: 2016 start-page: 1 year: 2016 end-page: 10 ident: CR64 article-title: Resveratrol protects against sepsis-associated encephalopathy and inhibits the NLRP3/IL-1 β axis in microglia publication-title: Mediators of Inflammation doi: 10.1155/2016/1045657 – volume: 179 start-page: 102 year: 2016 end-page: 113 ident: CR56 article-title: Bone marrow stromal cells attenuate LPS-induced mouse acute liver injury via the prostaglandin E 2-dependent repression of the NLRP3 inflammasome in Kupffer cells publication-title: Immunology Letters doi: 10.1016/j.imlet.2016.09.009 – volume: 41 start-page: 1012 year: 2016 end-page: 1021 ident: CR18 article-title: Mechanism and regulation of NLRP3 inflammasome activation publication-title: Trends in Biochemical Sciences doi: 10.1016/j.tibs.2016.09.002 – start-page: 5685 year: 2016 end-page: 5695 ident: CR53 publication-title: Inhibition of hepatic cells pyroptosis attenuates CLP-induced acute liver injury – volume: 12 start-page: 1272 year: 2016 end-page: 1291 ident: CR31 article-title: SESN2/sestrin2 suppresses sepsis by inducing mitophagy and inhibiting NLRP3 activation in macrophages publication-title: Autophagy doi: 10.1080/15548627.2016.1183081 – volume: 152 start-page: 207 year: 2017 end-page: 217 ident: CR25 article-title: Caspase-11 non-canonical inflammasome: a critical sensor of intracellular lipopolysaccharide in macrophage-mediated inflammatory responses publication-title: Immunology doi: 10.1111/imm.12787 – volume: 219 start-page: 315 year: 2014 end-page: 322 ident: CR36 article-title: Immunobiology Dimethyl sulfoxide inhibits NLRP3 inflammasome activation publication-title: Immunobiology doi: 10.1016/j.imbio.2013.11.003 – volume: 348 start-page: 138 year: 2003 end-page: 150 ident: CR3 article-title: The pathophysiology and treatment of sepsis publication-title: The New England Journal of Medicine doi: 10.1056/NEJMra021333 – volume: 311 start-page: C83 year: 2016 end-page: C100 ident: CR24 article-title: NLRP3 inflammasome signaling is activated by low-level lysosome disruption but inhibited by extensive lysosome disruption: roles for K+ efflux and Ca2+ influx. American Journal of Physiology publication-title: Cellular Physiology doi: 10.1152/ajpcell.00298.2015 – volume: 198 start-page: 1253 year: 2017 end-page: 1262 ident: CR32 article-title: Deletion of NLRP3 augments survival during polymicrobial sepsis by decreasing autophagy and enhancing phagocytosis publication-title: The Journal of Immunology doi: 10.4049/jimmunol.1601745 – volume: 111 start-page: 960 year: 2014 end-page: 965 ident: CR41 article-title: UCP2 transports C4 metabolites out of mitochondria, regulating glucose and glutamine oxidation publication-title: PNAS doi: 10.1073/pnas.1317400111 – volume: 52 start-page: 8 year: 2018 end-page: 17 ident: CR19 article-title: Ion homeostasis and ion channels in NLRP3 inflammasome activation and regulation publication-title: Current Opinion in Immunology doi: 10.1016/j.coi.2018.03.010 – ident: CR17 – volume: 179 start-page: 277 year: 2015 end-page: 293 ident: CR54 article-title: Gene silencing of non-obese diabetic receptor family (NLRP3) protects against the sepsis-induced hyper-bile acidaemia in a rat model publication-title: Clinical and Experimental Immunology doi: 10.1111/cei.12457 – volume: 6 start-page: 33201 year: 2016 ident: CR58 article-title: Protective effects of sirtuin 3 in a murine model of sepsis-induced acute kidney injury publication-title: Scientific Reports doi: 10.1038/srep33201 – volume: 13 start-page: 1 year: 2018 end-page: 9 ident: CR2 article-title: Raising concerns about the sepsis-3 definitions publication-title: World Journal of Emergency Surgery doi: 10.1186/s13017-018-0165-6 – volume: 109 start-page: 11282 issue: 28 year: 2012 end-page: 11287 ident: CR44 article-title: Critical role for calcium mobilization in activation of the NLRP3 inflammasome publication-title: Proceedings of the National Academy of Sciences doi: 10.1073/pnas.1117765109 – volume: 49 start-page: 529 year: 2016 end-page: 535 ident: CR30 article-title: Mitophagy: a balance regulator of NLRP3 inflammasome activation publication-title: BMB Reports doi: 10.5483/BMBRep.2016.49.10.115 – volume: 32 start-page: 78 year: 2015 end-page: 83 ident: CR26 article-title: Non-canonical activation of inflammatory caspases by cytosolic LPS in innate immunity publication-title: Current Opinion in Immunology doi: 10.1016/j.coi.2015.01.007 – volume: 196 start-page: 713 year: 2017 end-page: 726 ident: CR33 article-title: NLRP3 inflammasome deficiency protects against microbial sepsis via increased lipoxin B4 synthesis publication-title: American Journal of Respiratory and Critical Care Medicine doi: 10.1164/rccm.201604-0892OC – volume: 30 start-page: 82 year: 2012 end-page: 90 ident: CR12 article-title: Protective and aggravating fffects of NLRP3 inflammasome activation in IBD models: influence of genetic and environmental afctors publication-title: Digestive Diseases doi: 10.1159/000341681 – volume: 9 start-page: 2 year: 2002 end-page: 10 ident: CR7 article-title: Toll-like receptors: how they work and what they do publication-title: Current Opinion in Hematology doi: 10.1097/00062752-200201000-00002 – volume: 24 start-page: 443 year: 2017 end-page: 451 ident: CR15 article-title: Role of NLRP3 inflammasomes in atherosclerosis publication-title: Journal of Atherosclerosis and Thrombosis doi: 10.5551/jat.RV17001 – volume: 39 start-page: 393 year: 2018 ident: 1124_CR23 publication-title: Trends in Immunology doi: 10.1016/j.it.2018.01.009 – volume: 111 start-page: 960 year: 2014 ident: 1124_CR41 publication-title: PNAS doi: 10.1073/pnas.1317400111 – volume: 24 start-page: 443 year: 2017 ident: 1124_CR15 publication-title: Journal of Atherosclerosis and Thrombosis doi: 10.5551/jat.RV17001 – volume: 145 start-page: 300 issue: 2 year: 2015 ident: 1124_CR34 publication-title: Immunology doi: 10.1111/imm.12450 – volume: 109 start-page: 11282 issue: 28 year: 2012 ident: 1124_CR44 publication-title: Proceedings of the National Academy of Sciences doi: 10.1073/pnas.1117765109 – volume: 6 start-page: 31649 year: 2016 ident: 1124_CR38 publication-title: Scientific Reports doi: 10.1038/srep31649 – volume-title: Cardiac fibroblasts contribute to myocardial dysfunction in mice with sepsis : the role of NLRP3 inflammasome activation year: 2014 ident: 1124_CR49 doi: 10.1371/journal.pone.0107639 – volume: 49 start-page: 529 year: 2016 ident: 1124_CR30 publication-title: BMB Reports doi: 10.5483/BMBRep.2016.49.10.115 – volume: 86 start-page: 10 year: 2017 ident: 1124_CR43 publication-title: Molecular Immunology doi: 10.1016/j.molimm.2017.02.013 – volume: 179 start-page: 277 year: 2015 ident: 1124_CR54 publication-title: Clinical and Experimental Immunology doi: 10.1111/cei.12457 – volume: 20 start-page: 24 year: 2014 ident: 1124_CR61 publication-title: International Immunopharmacology doi: 10.1016/j.intimp.2014.02.017 – volume: 219 start-page: 315 year: 2014 ident: 1124_CR36 publication-title: Immunobiology doi: 10.1016/j.imbio.2013.11.003 – volume: 32 start-page: 78 year: 2015 ident: 1124_CR26 publication-title: Current Opinion in Immunology doi: 10.1016/j.coi.2015.01.007 – volume: 52 start-page: 8 year: 2018 ident: 1124_CR19 publication-title: Current Opinion in Immunology doi: 10.1016/j.coi.2018.03.010 – volume: 15 start-page: 169 year: 2014 ident: 1124_CR4 publication-title: Clinical Pediatric Emergency Medicine doi: 10.1016/j.cpem.2014.04.007 – volume: 348 start-page: 138 year: 2003 ident: 1124_CR3 publication-title: The New England Journal of Medicine doi: 10.1056/NEJMra021333 – volume: 196 start-page: 713 year: 2017 ident: 1124_CR33 publication-title: American Journal of Respiratory and Critical Care Medicine doi: 10.1164/rccm.201604-0892OC – volume: 9 start-page: e107072 issue: 9 year: 2014 ident: 1124_CR39 publication-title: PLoS ONE doi: 10.1371/journal.pone.0107072 – volume: 179 start-page: 102 year: 2016 ident: 1124_CR56 publication-title: Immunology Letters doi: 10.1016/j.imlet.2016.09.009 – volume: 6 start-page: 1 year: 2015 ident: 1124_CR20 publication-title: Frontiers in Pharmacology doi: 10.3389/fphar.2015.00262 – volume: 103 start-page: 115 year: 2018 ident: 1124_CR21 publication-title: Molecular Immunology doi: 10.1016/j.molimm.2018.09.010 – ident: 1124_CR17 doi: 10.1111/nyas.12458.Mechanism – volume: 39 start-page: 296 year: 2017 ident: 1124_CR62 publication-title: Immunopharmacology and Immunotoxicology doi: 10.1080/08923973.2017.1355377 – ident: 1124_CR22 doi: 10.3389/fimmu.2017.00036 – start-page: 5685 volume-title: Inhibition of hepatic cells pyroptosis attenuates CLP-induced acute liver injury year: 2016 ident: 1124_CR53 – volume: 41 start-page: 1012 year: 2016 ident: 1124_CR18 publication-title: Trends in Biochemical Sciences doi: 10.1016/j.tibs.2016.09.002 – volume: 166 start-page: 1 year: 2015 ident: 1124_CR37 publication-title: Journal of Ethnopharmacology doi: 10.1016/j.jep.2015.02.056 – volume: 152 start-page: 207 year: 2017 ident: 1124_CR25 publication-title: Immunology doi: 10.1111/imm.12787 – volume: 11 start-page: 477 year: 2018 ident: 1124_CR8 publication-title: Journal of Inflammation Research doi: 10.2147/JIR.S178084 – volume: 42 start-page: 306 year: 2019 ident: 1124_CR65 publication-title: Inflammation doi: 10.1007/s10753-018-0894-4 – volume: 13 start-page: 255 year: 2014 ident: 1124_CR47 publication-title: Nature Immunology doi: 10.1038/ni.2215.Activation – volume: 311 start-page: C83 year: 2016 ident: 1124_CR24 publication-title: Cellular Physiology doi: 10.1152/ajpcell.00298.2015 – volume: 12 start-page: 222 year: 2011 ident: 1124_CR48 publication-title: Nature Immunology doi: 10.1038/ni.1980.Autophagy – volume: 7 start-page: e14073 issue: 9 year: 2019 ident: 1124_CR52 publication-title: Physiological Reports doi: 10.14814/phy2.14073 – volume: 42 start-page: 1301 year: 2019 ident: 1124_CR63 publication-title: Inflammation doi: 10.1007/s10753-019-00990-7 – volume: 19 start-page: 184 issue: 2 year: 2018 ident: 1124_CR1 publication-title: Surgical Infections doi: 10.1089/sur.2017.298 – ident: 1124_CR42 doi: 10.1172/JCI78253.interact – volume: 9 start-page: 2 year: 2002 ident: 1124_CR7 publication-title: Current Opinion in Hematology doi: 10.1097/00062752-200201000-00002 – volume: 21 start-page: 426 year: 2015 ident: 1124_CR51 publication-title: Journal of Cardiac Failure doi: 10.1016/j.cardfail.2015.01.002 – volume: 11 start-page: 1 year: 2017 ident: 1124_CR11 publication-title: Frontiers in Cellular Neuroscience doi: 10.3389/fncel.2017.00063 – volume: 36 start-page: 1925 year: 2008 ident: 1124_CR40 publication-title: Sepsis induces brain mitochondrial dysfunction doi: 10.1097/CCM.0b013e3181760c4b – start-page: 20595 volume-title: Exogenous carbon monoxide decreases sepsis-induced acute kidney injury and inhibits NLRP3 inflammasome activation in rats year: 2015 ident: 1124_CR59 doi: 10.3390/ijms160920595 – volume: 92 start-page: 819 year: 2017 ident: 1124_CR16 publication-title: Biomedicine and Pharmacotherapy doi: 10.1016/j.biopha.2017.05.126 – volume: 13 start-page: 1 year: 2018 ident: 1124_CR2 publication-title: World Journal of Emergency Surgery doi: 10.1186/s13017-018-0165-6 – volume: 23 start-page: 201 issue: 2 year: 2013 ident: 1124_CR35 publication-title: Cell Research doi: 10.1038/cr.2013.6 – volume: 464 start-page: 1357 year: 2010 ident: 1124_CR13 publication-title: Nature doi: 10.1038/nature08938 – volume: 55 start-page: 1 year: 2017 ident: 1124_CR14 publication-title: Molecular Neurobiology. Molecular Neurobiology doi: 10.1007/s12035-016-0356-7 – volume: 10 start-page: e0120700 issue: 3 year: 2015 ident: 1124_CR57 publication-title: PLOS ONE doi: 10.1371/journal.pone.0120700 – volume: 25 start-page: 856 year: 2017 ident: 1124_CR55 publication-title: Cell Metabolism doi: 10.1016/j.cmet.2017.03.007 – volume: 44 start-page: 1467 issue: 5 year: 2014 ident: 1124_CR29 publication-title: European Journal of Immunology doi: 10.1002/eji.201344063 – volume: 2016 start-page: 1 year: 2016 ident: 1124_CR64 publication-title: Mediators of Inflammation doi: 10.1155/2016/1045657 – volume: 5 start-page: 34 year: 2017 ident: 1124_CR5 publication-title: Vaccines doi: 10.3390/vaccines5040034 – volume: 30 start-page: 82 year: 2012 ident: 1124_CR12 publication-title: Digestive Diseases doi: 10.1159/000341681 – volume: 50 start-page: 32 year: 2018 ident: 1124_CR9 publication-title: Current Opinion in Immunology doi: 10.1016/j.coi.2017.10.011 – volume: 284 start-page: 24035 issue: 36 year: 2009 ident: 1124_CR28 publication-title: Journal of Biological Chemistry doi: 10.1074/jbc.M109.014266 – volume: 6 start-page: 33201 year: 2016 ident: 1124_CR58 publication-title: Scientific Reports doi: 10.1038/srep33201 – volume: 198 start-page: 1253 year: 2017 ident: 1124_CR32 publication-title: The Journal of Immunology doi: 10.4049/jimmunol.1601745 – ident: 1124_CR60 doi: 10.18632/oncotarget.13010 – ident: 1124_CR45 doi: 10.2174/1389450117666160527143143 – volume: 17 start-page: 588 year: 2018 ident: 1124_CR10 publication-title: Nature Reviews Drug Discovery doi: 10.1038/nrd.2018.97 – volume: 34 start-page: 29 year: 2018 ident: 1124_CR27 publication-title: Critical Care Clinics doi: 10.1016/j.ccc.2017.08.002 – volume: 63 start-page: e12410 year: 2017 ident: 1124_CR50 publication-title: Journal of Pineal Research doi: 10.1111/jpi.12410 – volume: 12 start-page: 1272 year: 2016 ident: 1124_CR31 publication-title: Autophagy doi: 10.1080/15548627.2016.1183081 – volume: 7 start-page: 277 year: 2001 ident: 1124_CR6 publication-title: Journal of Endotoxin Research doi: 10.1177/09680519010070040901 – ident: 1124_CR46 doi: 10.1038/s41467-017-00213-3 |
| SSID | ssj0008983 |
| Score | 2.5840678 |
| SecondaryResourceType | review_article |
| Snippet | The pathophysiology of sepsis is extremely complex. During this disease, the exacerbation of the inflammatory response causes oxidative stress, alterations in... AbstractThe pathophysiology of sepsis is extremely complex. During this disease, the exacerbation of the inflammatory response causes oxidative stress,... |
| SourceID | proquest pubmed crossref springer |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 24 |
| SubjectTerms | Animals Biomedical and Life Sciences Biomedicine Caspase-1 Cytokines - metabolism Humans IL-1β Immunology Inflammasomes Inflammasomes - immunology Inflammasomes - metabolism Inflammation Interleukin 18 Internal Medicine Macromolecules Mitochondria NLR Family, Pyrin Domain-Containing 3 Protein - metabolism Oxidative stress Pathology Pharmacology/Toxicology Review Rheumatology Sepsis Sepsis - immunology Sepsis - metabolism Sepsis - physiopathology Signal Transduction |
| SummonAdditionalLinks | – databaseName: SpringerLink Journals (ICM) dbid: U2A link: http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV3dS8MwED90gvgifludEsE3LbRN2zSPQxybuCHTwd5K2iYw2Lphu__fS782mQo-95q0d0nud_zuLgD3ccyFlWCQY0VMmC5NAjOSSplUMsFsT0jH0oXCg6HfG7svE29SFYVldbZ7TUkWJ_VGsRtCawx9dX4PeiWT78Kep2N3XMVjp9OcvwEvm29SH08YzllVKvPzGN_d0RbG3OJHC7fTPYLDCi-STmngY9iR6QnsDypG_BQ42pkMX0dvlPRTheadi2wxl0SkCennGRktZpJMU_Iul9k0Ixs5Qmcw7j5_PPXM6joEM6bMy81IQ33cg44MfMUijB0STUtyJlxb15vG6O1ZEttCIEbRhB7-olKxRMBmC5b49Bxa6SKVl0AspVzhMkFdGrjUEZEXW1zZjvIiEaCkAXatlTCueoXrKytm4brLsdZkiJoMC02G3ICH5p1l2SnjT-l2reyw2jVZ6GhWEwGk5Rtw1zzG9a5JDJHKxUrLIADzdVd7Ay5KIzXTIRZyNS1qwGNttfXgv3_L1f_Er-HA0UF3kbrdhlb-uZI3iEzy6LZYiF-I39PG priority: 102 providerName: Springer Nature |
| Title | The NLRP3 Inflammasome and Its Role in Sepsis Development |
| URI | https://link.springer.com/article/10.1007/s10753-019-01124-9 https://www.ncbi.nlm.nih.gov/pubmed/31741197 https://www.proquest.com/docview/2351105706 https://www.proquest.com/docview/2315969155 |
| Volume | 43 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwfV3dT9swED8xkNBeEGMDAgx50t62iCRO4vgJlap8bVSoUKk8RY5jS5UgKaT8_9ylbgtC8JJIiZM4d7bvd74vgN9aSxWUqOQEhVB-zMvML4y1PjdCiTBRJgooUPiqn54P48tRMnIbbo1zq5yvie1CXdaa9siPIrJ4IbgI0uPJo09Vo8i66kpofIE1Sl1GLl1itFC4gkzO0nDyFNcaKYULmnGhcwjUUZEmbyGUcb58K5jeoc13ltJWAJ1uwoZDjqwzY_U3WDHVFqxfOdv4d5DIcdb_P7jm7KKyyOgH1dQPhqmqZBfThg3qe8PGFbsxk2bcsFfeQj9geNq77Z77rjCCr7lIpn5BoB9nY2Sy1IoCtYiSDJRSqDikyFONcl-UOlQK0QqZ9vAXrdUGoVuoRJnybVit6srsAgusjVUsFI95FvNIFYkOpA0jmxQqw5YehHOq5NplDafiFff5Mt8xUTJHSuYtJXPpwZ_FM5NZzoxPWx_MiZ27-dPkS2578GtxG0c-mTNUZepnaoNQLKX89h7szJi0-ByiopgMpB78nXNt-fKP-7L3eV_24WtE6nbrtH0Aq9OnZ_MTMcm0OGwH3iGsdc7u_vXwfNLrXw_wajft4nEYdV4A4Tzbvw |
| linkProvider | ProQuest |
| linkToHtml | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LT9wwEB7RRWp7qaDPFEpdqT21VpPYiZMDqloe2i27K7QFiVvqOLaEBMm2WVTxp_iNzGySXSoEN85xHGs89nyTbx4AH41JtV-gk-PnSnMpioTn1jkurNIqiLQNfUoUHo3j_rH8eRKdrMBVlwtDYZXdnTi_qIvK0D_yryExXggu_Pjb9A-nrlHErnYtNBq1OLCX_9Blq7cHu7i_n8Jwf-9op8_brgLcCBXNeE6IGVU5tEnsVI4QvCB2L1VaBpS2adBoqsIEWqOpJ14MT4BzxiLuCbQqYoHzPoJVKdCV6cHqj73x4WRx9ydpU_gTH3I0_apN02mT9dA1QNed4pPQqvL0f1N4C9_e4mbnJm9_DZ61WJV9b5RrHVZs-Rwej1o2_gWkqGNsPJwcCjYoHarWua6rc8t0WbDBrGaT6syy05L9stP6tGY34pNewvGDCO0V9MqqtG-A-c5JLZUWUiRShDqPjJ-6IHRRrhMc6UHQSSUzbZ1yapdxli0rLJMkM5RkNpdklnrwefHOtKnSce_ozU7YWXti62ypXx58WDzGs0YEii5tdUFjEPzFVFHfg9fNJi0-hzhMEiXrwZdu15aT372Wt_ev5T086R-NhtlwMD7YgKchOfvzkPFN6M3-Xth3iIhm-Varhgx-P7TmXwNZExIj |
| linkToPdf | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV1LT9wwEB5RkFAviNIWwqO4UntqI5I4ieMDQlVhxfJYIVqkvQXHsSUkSBayCPHX-HXM5LELQnDjHMexxt94vsk8DPBDa6m8HJ0cLxPKDXmeuJmx1uVGKOFHygQeFQofD-L9s_BgGA1n4KGrhaG0yu5MrA_qvNT0j3wroIgXkgsv3rJtWsTJbm9ndO3SDVIUae2u02ggcmju79B9q7b7u7jXP4Ogt_f_777b3jDgai6isZsRe0ZYByaJrciQjucU6ZNChT6VcGo0oCLXvlJo9ilGhtpgrTbIgXwl8pjjvB9gTuDaSMfEcOLseYlsWoDyGM85KUVbsNOW7aGTgE48ZSqhfXXlc6P4gum-iNLWxq-3CAsta2V_Gph9ghlTLMH8cRuX_wwS0cYGR6cnnPULiyC7UlV5ZZgqctYfV-y0vDTsomD_zKi6qNiTTKUvcPYuIvsKs0VZmBVgnrWhCoXiIU9CHqgs0p60fmCjTCU40gG_k0qq247ldHHGZTrttUySTFGSaS3JVDrwa_LOqOnX8ebo9U7Yaau7VTpFmgPfJ49R6yiUogpT3tIYpIEx9dZ3YLnZpMnnkJGFFJx14He3a9PJX1_L6ttr2YR5xHt61B8crsHHgLz-Ond8HWbHN7dmA6nROPtWY5DB-XuD_hG8ORTz |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=The+NLRP3+Inflammasome+and+Its+Role+in+Sepsis+Development&rft.jtitle=Inflammation&rft.au=Danielski%2C+Lucin%C3%A9ia+Gainski&rft.au=Giustina%2C+Amanda+Della&rft.au=Bonfante%2C+Sandra&rft.au=Barichello%2C+Tatiana&rft.date=2020-02-01&rft.eissn=1573-2576&rft.volume=43&rft.issue=1&rft.spage=24&rft_id=info:doi/10.1007%2Fs10753-019-01124-9&rft_id=info%3Apmid%2F31741197&rft.externalDocID=31741197 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0360-3997&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0360-3997&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0360-3997&client=summon |