Epigenetic Mechanisms of Aluminum-Induced Neurotoxicity and Alzheimer’s Disease: A Focus on Non-Coding RNAs

• Published in: Neurochemical research Vol. 49; no. 11; pp. 2988 - 3005
• Main Authors: Aschner, Michael, Skalny, Anatoly V., Santamaria, Abel, Rocha, Joao B. T., Mansouri, Borhan, Tizabi, Yousef, Madeddu, Roberto, Lu, Rongzu, Lee, Eunsook, Tinkov, Alexey A.
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.11.2024; Springer Nature B.V
• Subjects: Acetylation; Aluminum; Aluminum - toxicity; Alzheimer Disease - genetics; Alzheimer Disease - metabolism; Alzheimer's disease; Amyloid precursor protein; Animals; Biochemistry; Biomedical and Life Sciences; Biomedicine; Brain-derived neurotrophic factor; Cell Biology; Cognitive ability; Deoxyribonucleic acid; DNA; DNA methylation; DNA Methylation - drug effects; Down-regulation; Epigenesis, Genetic - drug effects; Epigenetics; Exposure; Gene expression; Histones; Humans; MicroRNAs; MicroRNAs - genetics; MicroRNAs - metabolism; miRNA; Neurochemistry; Neurodegenerative diseases; Neurology; Neurosciences; Neurotoxicity; Neurotoxicity Syndromes - etiology; Neurotoxicity Syndromes - metabolism; NF-κB protein; Non-coding RNA; Pathogenesis; Pathology; Proteins; Review; RNA, Untranslated - genetics; RNA, Untranslated - metabolism; Secretase; Translocation; Up-regulation; β-Amyloid; β-Site APP-cleaving enzyme 1; DNA methylation; microRNA; Histone; Aluminum; Long non-coding RNA

Aluminum (Al) is known to induce neurotoxic effects, potentially contributing to Alzheimer’s disease (AD) pathogenesis. Recent studies suggest that epigenetic modification may contribute to Al neurotoxicity, although the mechanisms are still debatable. Therefore, the objective of the present study w...