Elevated serum levels of interleukin-10 in adult-onset Still’s disease are associated with disease activity

• Published in: Clinical rheumatology Vol. 38; no. 11; pp. 3205 - 3210
• Main Authors: Sun, Yue, Wang, Zhihong, Chi, Huihui, Hu, Qiongyi, Ye, Junna, Liu, Honglei, Cheng, Xiaobing, Shi, Hui, Zhou, Zhuochao, Teng, Jialin, Yang, Chengde, Su, Yutong
• Format: Journal Article
• Language: English
• Published: London Springer London 01.11.2019; Springer Nature B.V
• Subjects: Adult; Arthralgia; Brief Report; C-reactive protein; Case-Control Studies; China - epidemiology; Cytokines; Erythrocyte sedimentation rate; Female; Ferritin; Fever; Humans; IL-1β; Inflammatory diseases; Interleukin 10; Interleukin 18; Interleukin 6; Interleukin-10 - blood; Lymphadenopathy; Male; Medicine; Medicine & Public Health; Middle Aged; Pharyngitis; Pharynx; Rheumatology; Serum levels; Splenomegaly; Still's Disease, Adult-Onset - blood; Still's Disease, Adult-Onset - epidemiology; Tumor necrosis factor-α; Young Adult; China; Inflammation; Disease activity; Adult-onset Still’s disease; IL-10
• ISSN: 0770-3198; 1434-9949; 1434-9949
• DOI: 10.1007/s10067-019-04642-x

To evaluate the serum levels of the anti-inflammatory cytokine interleukin-10 (IL-10) in patients with adult-onset Still’s disease (AOSD), a rare, systemic, and multigenic inflammatory disease. The serum levels of IL-10, IL-1β, IL-6, IL-18, and TNF-α were examined by electrochemiluminescence assay. The serum levels of IL-10 were higher in AOSD patients than in healthy controls and positively correlated with systemic score, erythrocyte sedimentation rate (ESR), C-reactive protein level (CRP), ferritin, and inflammatory cytokine (IL-1β, IL-6, IL-18, and TNF-α) levels. Moreover, the levels of IL-10 were significantly higher in AOSD patients who had fever, sore throat, rash, lymphadenopathy, splenomegaly, pneumonia, and arthralgia than in patients who did not. IL-10 was increased in AOSD patients and correlated with disease activity. Key Points • In this manuscript, we confirmed the elevated serum levels of the anti-inflammatory cytokine IL-10 in AOSD patients, which was previously poorly defined. • We revealed for the first time that the levels of IL-10 were correlated with disease activity and inflammatory cytokine levels in AOSD.