Effect of magnesium supplementation on lactate clearance in critically ill patients with severe sepsis: a randomized clinical trial
Objectives In this study, changes in lactate clearance following magnesium supplementation were evaluated in critically ill patients with severe sepsis. Methods Fifty-eight patients with severe sepsis were randomly assigned to receive either magnesium ( n = 30) or placebo ( n = 28). Patients in the...
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| Published in | European journal of clinical pharmacology Vol. 76; no. 2; pp. 175 - 184 |
|---|---|
| Main Authors | , , , |
| Format | Journal Article |
| Language | English |
| Published |
Berlin/Heidelberg
Springer Berlin Heidelberg
01.02.2020
Springer Nature B.V |
| Subjects | |
| Online Access | Get full text |
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| Abstract | Objectives
In this study, changes in lactate clearance following magnesium supplementation were evaluated in critically ill patients with severe sepsis.
Methods
Fifty-eight patients with severe sepsis were randomly assigned to receive either magnesium (
n
= 30) or placebo (
n
= 28). Patients in the magnesium group received intravenous magnesium sulfate to maintain serum magnesium level around 3 mg/dL for 3 days. The placebo group received the same volume of normal saline. Change in lactate clearance was considered primary outcome of the study.
Results
Mean increase in the lactate clearance in the magnesium group was significantly higher than the placebo group on day 2 (27.53% vs. 23.79% respectively,
p
< 0.001) and day 3 (49.83% vs. 37.02% respectively,
p
< 0.001). Time to lactate clearance was also significantly shorter in the magnesium group than the placebo group (47.28 ± 20.59 vs. 61.20 ± 24.31 h respectively,
p
= 0.03). Sepsis-related mortality was not significantly different but median length of ICU stay was significantly shorter in the magnesium group than the placebo group (8 vs. 15 days respectively,
p
< 0.01).
Conclusions
Magnesium supplementation increased lactate clearance in critically ill patients with severe sepsis. Optimizing serum magnesium level near the upper limit of the normal range may improve severe sepsis outcomes. |
|---|---|
| AbstractList | In this study, changes in lactate clearance following magnesium supplementation were evaluated in critically ill patients with severe sepsis.OBJECTIVESIn this study, changes in lactate clearance following magnesium supplementation were evaluated in critically ill patients with severe sepsis.Fifty-eight patients with severe sepsis were randomly assigned to receive either magnesium (n = 30) or placebo (n = 28). Patients in the magnesium group received intravenous magnesium sulfate to maintain serum magnesium level around 3 mg/dL for 3 days. The placebo group received the same volume of normal saline. Change in lactate clearance was considered primary outcome of the study.METHODSFifty-eight patients with severe sepsis were randomly assigned to receive either magnesium (n = 30) or placebo (n = 28). Patients in the magnesium group received intravenous magnesium sulfate to maintain serum magnesium level around 3 mg/dL for 3 days. The placebo group received the same volume of normal saline. Change in lactate clearance was considered primary outcome of the study.Mean increase in the lactate clearance in the magnesium group was significantly higher than the placebo group on day 2 (27.53% vs. 23.79% respectively, p < 0.001) and day 3 (49.83% vs. 37.02% respectively, p < 0.001). Time to lactate clearance was also significantly shorter in the magnesium group than the placebo group (47.28 ± 20.59 vs. 61.20 ± 24.31 h respectively, p = 0.03). Sepsis-related mortality was not significantly different but median length of ICU stay was significantly shorter in the magnesium group than the placebo group (8 vs. 15 days respectively, p < 0.01).RESULTSMean increase in the lactate clearance in the magnesium group was significantly higher than the placebo group on day 2 (27.53% vs. 23.79% respectively, p < 0.001) and day 3 (49.83% vs. 37.02% respectively, p < 0.001). Time to lactate clearance was also significantly shorter in the magnesium group than the placebo group (47.28 ± 20.59 vs. 61.20 ± 24.31 h respectively, p = 0.03). Sepsis-related mortality was not significantly different but median length of ICU stay was significantly shorter in the magnesium group than the placebo group (8 vs. 15 days respectively, p < 0.01).Magnesium supplementation increased lactate clearance in critically ill patients with severe sepsis. Optimizing serum magnesium level near the upper limit of the normal range may improve severe sepsis outcomes.CONCLUSIONSMagnesium supplementation increased lactate clearance in critically ill patients with severe sepsis. Optimizing serum magnesium level near the upper limit of the normal range may improve severe sepsis outcomes. Objectives In this study, changes in lactate clearance following magnesium supplementation were evaluated in critically ill patients with severe sepsis. Methods Fifty-eight patients with severe sepsis were randomly assigned to receive either magnesium ( n = 30) or placebo ( n = 28). Patients in the magnesium group received intravenous magnesium sulfate to maintain serum magnesium level around 3 mg/dL for 3 days. The placebo group received the same volume of normal saline. Change in lactate clearance was considered primary outcome of the study. Results Mean increase in the lactate clearance in the magnesium group was significantly higher than the placebo group on day 2 (27.53% vs. 23.79% respectively, p < 0.001) and day 3 (49.83% vs. 37.02% respectively, p < 0.001). Time to lactate clearance was also significantly shorter in the magnesium group than the placebo group (47.28 ± 20.59 vs. 61.20 ± 24.31 h respectively, p = 0.03). Sepsis-related mortality was not significantly different but median length of ICU stay was significantly shorter in the magnesium group than the placebo group (8 vs. 15 days respectively, p < 0.01). Conclusions Magnesium supplementation increased lactate clearance in critically ill patients with severe sepsis. Optimizing serum magnesium level near the upper limit of the normal range may improve severe sepsis outcomes. ObjectivesIn this study, changes in lactate clearance following magnesium supplementation were evaluated in critically ill patients with severe sepsis.MethodsFifty-eight patients with severe sepsis were randomly assigned to receive either magnesium (n = 30) or placebo (n = 28). Patients in the magnesium group received intravenous magnesium sulfate to maintain serum magnesium level around 3 mg/dL for 3 days. The placebo group received the same volume of normal saline. Change in lactate clearance was considered primary outcome of the study.ResultsMean increase in the lactate clearance in the magnesium group was significantly higher than the placebo group on day 2 (27.53% vs. 23.79% respectively, p < 0.001) and day 3 (49.83% vs. 37.02% respectively, p < 0.001). Time to lactate clearance was also significantly shorter in the magnesium group than the placebo group (47.28 ± 20.59 vs. 61.20 ± 24.31 h respectively, p = 0.03). Sepsis-related mortality was not significantly different but median length of ICU stay was significantly shorter in the magnesium group than the placebo group (8 vs. 15 days respectively, p < 0.01).ConclusionsMagnesium supplementation increased lactate clearance in critically ill patients with severe sepsis. Optimizing serum magnesium level near the upper limit of the normal range may improve severe sepsis outcomes. In this study, changes in lactate clearance following magnesium supplementation were evaluated in critically ill patients with severe sepsis. Fifty-eight patients with severe sepsis were randomly assigned to receive either magnesium (n = 30) or placebo (n = 28). Patients in the magnesium group received intravenous magnesium sulfate to maintain serum magnesium level around 3 mg/dL for 3 days. The placebo group received the same volume of normal saline. Change in lactate clearance was considered primary outcome of the study. Mean increase in the lactate clearance in the magnesium group was significantly higher than the placebo group on day 2 (27.53% vs. 23.79% respectively, p < 0.001) and day 3 (49.83% vs. 37.02% respectively, p < 0.001). Time to lactate clearance was also significantly shorter in the magnesium group than the placebo group (47.28 ± 20.59 vs. 61.20 ± 24.31 h respectively, p = 0.03). Sepsis-related mortality was not significantly different but median length of ICU stay was significantly shorter in the magnesium group than the placebo group (8 vs. 15 days respectively, p < 0.01). Magnesium supplementation increased lactate clearance in critically ill patients with severe sepsis. Optimizing serum magnesium level near the upper limit of the normal range may improve severe sepsis outcomes. |
| Author | Mohammadi, Mostafa Abdollahi, Alireza Noormandi, Afsaneh Khalili, Hossein |
| Author_xml | – sequence: 1 givenname: Afsaneh surname: Noormandi fullname: Noormandi, Afsaneh organization: Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences – sequence: 2 givenname: Hossein orcidid: 0000-0002-1590-6396 surname: Khalili fullname: Khalili, Hossein email: khalilih@tums.ac.ir organization: Department of Clinical Pharmacy, Faculty of Pharmacy, Tehran University of Medical Sciences – sequence: 3 givenname: Mostafa surname: Mohammadi fullname: Mohammadi, Mostafa organization: Department of Intensive Care Unit, Imam Khomeini Hospital, Faculty of Medicine, Tehran University of Medical Sciences – sequence: 4 givenname: Alireza surname: Abdollahi fullname: Abdollahi, Alireza organization: Department of Pathology, Faculty of Medicine, Tehran University of Medical Sciences |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31814044$$D View this record in MEDLINE/PubMed |
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| CitedBy_id | crossref_primary_10_3390_nu16233985 crossref_primary_10_3390_vaccines11061122 crossref_primary_10_1007_s12011_024_04368_1 crossref_primary_10_1097_SHK_0000000000002263 crossref_primary_10_1080_08830185_2021_1974856 crossref_primary_10_1016_j_intimp_2024_111870 crossref_primary_10_1186_s13063_022_06077_3 crossref_primary_10_1016_j_clnu_2024_03_030 crossref_primary_10_1016_j_wneu_2024_09_059 crossref_primary_10_1186_s44158_024_00158_2 crossref_primary_10_3389_fphar_2020_594321 crossref_primary_10_2217_cer_2020_0238 crossref_primary_10_1016_j_bja_2023_08_005 crossref_primary_10_1111_aas_14186 crossref_primary_10_1038_s41392_022_01151_3 crossref_primary_10_2217_fmb_2022_0044 |
| Cites_doi | 10.1097/CCM.0000000000003311 10.5847/wjem.j.1920-8642.2017.03.004 10.1007/s00134-018-5213-x 10.1097/SHK.0000000000000769 10.1093/qjmed/hcw048 10.1097/00003246-199401000-00438 10.1007/s00134-012-2769-8 10.1186/s40560-018-0291-y 10.1177/0884533614561790 10.1016/j.jcrc.2015.07.029 10.4103/0972-5229.160272 10.18410/jebmh/2017/805 10.1378/chest.15-1703 10.1097/SHK.0000000000001128 10.1371/journal.pone.0145181 10.14740/jocmr2351w 10.1016/j.jcrc.2010.03.003 10.1177/0884533617695243 10.1016/j.jcrc.2016.09.023 10.1001/jama.2017.10913 10.1016/j.jcrc.2018.08.035 10.1097/00003246-199711000-00024 10.14260/Jemds/2017/722 10.1177/0885066614530659 10.1186/s12967-018-1700-7 10.1111/vec.12213 10.1097/SHK.0000000000001055 10.1186/2110-5820-3-3 10.1016/S0946-672X(00)80037-1 10.1177/0885066618777431 10.1042/bj0800099 10.5772/25925 |
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| Keywords | Sepsis Magnesium Lactate Severe sepsis Lactate clearance |
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| References | Boysen, Dorval (CR30) 2014; 24 Marty, Roquilly, Vallée, Luzi, Ferré, Fourcade (CR19) 2013; 3 Gupta, Bindra, Batada, Gupta (CR9) 2016; 17 Moskowitz, Lee, Donnino, Mark, Celi, Danziger (CR8) 2016; 31 Suetrong, Walley (CR11) 2016; 149 Ding, Yang, Xu, Li, Yuan, Guo (CR35) 2018; 16 Panahi, Mojtahedzadeh, Najafi, Ghaini, Abdollahi, Sharifzadeh (CR1) 2017; 16 CR13 Donnino, Carney, Cocchi, Barbash, Chase, Joyce (CR17) 2010; 25 Bernstein, Aduen, Bhaliani, Kerzner, Davison, Miller (CR25) 1994; 22 Londoño, Niño, Archila, Valencia, Cárdenas, Perdomo (CR18) 2018; 48 Taeb, Hooper, Marik (CR14) 2017; 32 Hansen, Bruserud (CR2) 2018; 6 Walther, Winnefeld, Sölch (CR22) 2000; 14 Dellinger, Levy, Rhodes, Annane, Gerlach, Opal (CR21) 2013; 39 Woolum, Abner, Kelly, Bastin, Morris, Flannery (CR27) 2018; 46 Miyamoto, Nakashima, Shima, Kato, Ueda, Kawazoe (CR34) 2018; 50 Hernandez, Bellomo, Bakker (CR32) 2018; 45 Didwania, Miller, Kassel, Jackson, Chernow (CR29) 1997; 25 Velissaris, Karamouzos, Pierrakos, Aretha, Karanikolas (CR7) 2015; 7 Jiang, Lv, Lai, Xu (CR10) 2017; 47 Lokhandwala, Andersen, Nair, Patel, Cocchi, Donnino (CR15) 2017; 37 Baig, Shahzad, Hussain, Mian (CR26) 2017; 8 CR6 Kamble, Patel, Trivedi (CR12) 2017; 4 Andrews, Semler, Muchemwa, Kelly, Lakhi, Heimburger (CR31) 2017; 318 Fairley, Glassford, Zhang, Bellomo (CR3) 2015; 30 CR24 Upala, Jaruvongvanich, Wijarnpreecha, Sanguankeo (CR4) 2016; 109 Giacalone, Martinelli, Abramo, Rubino, Pavoni, Iacconi (CR16) 2015; 30 Shin, Hwang, Jo, Kim, Ryoo, Kang (CR20) 2018; 50 Kumar, Honmode, Jain, Bhagat (CR5) 2015; 19 Lee, Kim, Kim, Jeong, Son, An (CR28) 2015; 10 Dawson, Heaton (CR23) 1961; 80 Elenjickal, Lakra (CR33) 2017; 6 JA Woolum (2788_CR27) 2018; 46 AM Taeb (2788_CR14) 2017; 32 K Miyamoto (2788_CR34) 2018; 50 J Londoño (2788_CR18) 2018; 48 Y Panahi (2788_CR1) 2017; 16 SM Lee (2788_CR28) 2015; 10 S Kumar (2788_CR5) 2015; 19 D Velissaris (2788_CR7) 2015; 7 Glenn Hernandez (2788_CR32) 2018; 45 S Kamble (2788_CR12) 2017; 4 B Andrews (2788_CR31) 2017; 318 N Elenjickal (2788_CR33) 2017; 6 2788_CR13 S Lokhandwala (2788_CR15) 2017; 37 B-A Hansen (2788_CR2) 2018; 6 X-F Ding (2788_CR35) 2018; 16 M Giacalone (2788_CR16) 2015; 30 MW Donnino (2788_CR17) 2010; 25 JB Dawson (2788_CR23) 1961; 80 J Shin (2788_CR20) 2018; 50 A Didwania (2788_CR29) 1997; 25 MA Baig (2788_CR26) 2017; 8 B Suetrong (2788_CR11) 2016; 149 WK Bernstein (2788_CR25) 1994; 22 A Moskowitz (2788_CR8) 2016; 31 2788_CR24 2788_CR6 SR Boysen (2788_CR30) 2014; 24 J Fairley (2788_CR3) 2015; 30 S Upala (2788_CR4) 2016; 109 P Jiang (2788_CR10) 2017; 47 RP Dellinger (2788_CR21) 2013; 39 L Walther (2788_CR22) 2000; 14 P Marty (2788_CR19) 2013; 3 S Gupta (2788_CR9) 2016; 17 |
| References_xml | – volume: 46 start-page: 1747 issue: 11 year: 2018 end-page: 1752 ident: CR27 article-title: Effect of thiamine administration on lactate clearance and mortality in patients with septic shock publication-title: Crit Care Med doi: 10.1097/CCM.0000000000003311 – volume: 8 start-page: 184 issue: 3 year: 2017 ident: CR26 article-title: Validating a point of care lactate meter in adult patients with sepsis presenting to the emergency department of a tertiary care hospital of a low-to middle-income country publication-title: World J Emerg Med doi: 10.5847/wjem.j.1920-8642.2017.03.004 – volume: 45 start-page: 82 issue: 1 year: 2018 end-page: 85 ident: CR32 article-title: The ten pitfalls of lactate clearance in sepsis publication-title: Intensive Care Medicine doi: 10.1007/s00134-018-5213-x – volume: 47 start-page: 288 issue: 3 year: 2017 end-page: 295 ident: CR10 article-title: Does hypomagnesemia impact on the outcome of patients admitted to the intensive care unit? A systematic review and meta-analysis publication-title: Shock doi: 10.1097/SHK.0000000000000769 – volume: 109 start-page: 453 issue: 7 year: 2016 end-page: 459 ident: CR4 article-title: Hypomagnesemia and mortality in patients admitted to intensive care unit: a systematic review and meta-analysis publication-title: QJM doi: 10.1093/qjmed/hcw048 – volume: 22 start-page: A228 issue: 1 year: 1994 ident: CR25 article-title: Simultaneous arterial and venous lactate determinations in critically ill patients publication-title: Crit Care Med doi: 10.1097/00003246-199401000-00438 – volume: 16 start-page: 464 year: 2017 end-page: 482 ident: CR1 article-title: The role of magnesium sulfate in the intensive care unit publication-title: EXCLI J – volume: 39 start-page: 165 issue: 2 year: 2013 end-page: 228 ident: CR21 article-title: Surviving Sepsis campaign: international guidelines for management of severe sepsis and septic shock, 2012 publication-title: Intensive Care Med doi: 10.1007/s00134-012-2769-8 – volume: 6 start-page: 21 issue: 1 year: 2018 ident: CR2 article-title: Hypomagnesemia in critically ill patients publication-title: J Intensive Care doi: 10.1186/s40560-018-0291-y – volume: 30 start-page: 104 issue: 1 year: 2015 end-page: 110 ident: CR16 article-title: Rapid reversal of severe lactic acidosis after thiamine administration in critically ill adults: a report of 3 cases publication-title: Nutr Clin Pract doi: 10.1177/0884533614561790 – volume: 30 start-page: 1349 issue: 6 year: 2015 end-page: 1358 ident: CR3 article-title: Magnesium status and magnesium therapy in critically ill patients: a systematic review publication-title: J Crit Care doi: 10.1016/j.jcrc.2015.07.029 – volume: 19 start-page: 379 issue: 7 year: 2015 ident: CR5 article-title: Does magnesium matter in patients of medical intensive care unit: a study in rural Central India publication-title: Indian J Crit Care Med doi: 10.4103/0972-5229.160272 – ident: CR6 – volume: 4 start-page: 4032 issue: 67 year: 2017 end-page: 4036 ident: CR12 article-title: Study of hypomagnesemia in critically-ill patients in medical intensive care unit at tertiary care hospital publication-title: JEBMH doi: 10.18410/jebmh/2017/805 – volume: 149 start-page: 252 issue: 1 year: 2016 end-page: 261 ident: CR11 article-title: Lactic acidosis in Sepsis: It's not all anaerobic: implications for diagnosis and management publication-title: CHEST doi: 10.1378/chest.15-1703 – volume: 50 start-page: 545 issue: 5 year: 2018 end-page: 550 ident: CR20 article-title: Prognostic value of the lactate/albumin ratio for predicting 28-day mortality in critically ILL Sepsis patients publication-title: Shock doi: 10.1097/SHK.0000000000001128 – volume: 10 issue: 12 year: 2015 ident: CR28 article-title: Lactate clearance and vasopressor seem to be predictors for mortality in severe sepsis patients with lactic acidosis supplementing sodium bicarbonate: a retrospective analysis publication-title: PLoS One doi: 10.1371/journal.pone.0145181 – volume: 7 start-page: 911 issue: 12 year: 2015 end-page: 918 ident: CR7 article-title: Hypomagnesemia in critically ill sepsis patients publication-title: J Clin Med Res doi: 10.14740/jocmr2351w – volume: 25 start-page: 576 issue: 4 year: 2010 end-page: 581 ident: CR17 article-title: Thiamine deficiency in critically ill patients with sepsis publication-title: J Crit Care doi: 10.1016/j.jcrc.2010.03.003 – volume: 80 start-page: 100 year: 1961 end-page: 106 ident: CR23 article-title: The determination of magnesium in biological materials by atomic absorption spectrophotometry publication-title: Biochem J – volume: 32 start-page: 296 issue: 3 year: 2017 end-page: 308 ident: CR14 article-title: Sepsis: current definition, pathophysiology, diagnosis, and management publication-title: Nutr Clin Pract doi: 10.1177/0884533617695243 – volume: 37 start-page: 179 year: 2017 end-page: 184 ident: CR15 article-title: Absolute lactate value vs relative reduction as a predictor of mortality in severe sepsis and septic shock publication-title: J Crit Care doi: 10.1016/j.jcrc.2016.09.023 – volume: 17 start-page: 37 issue: 1 year: 2016 ident: CR9 article-title: To study serum magnesium level and its correlation with prognostic significance in critically ill patients publication-title: JIACM – volume: 318 start-page: 1233 issue: 13 year: 2017 end-page: 1240 ident: CR31 article-title: Effect of an early resuscitation protocol on in-hospital mortality among adults with sepsis and hypotension: a randomized clinical trial publication-title: JAMA doi: 10.1001/jama.2017.10913 – volume: 48 start-page: 191 year: 2018 end-page: 197 ident: CR18 article-title: Antibiotics has more impact on mortality than other early goal-directed therapy components in patients with sepsis: An instrumental variable analysis publication-title: J Crit Care doi: 10.1016/j.jcrc.2018.08.035 – volume: 25 start-page: 1851 issue: 11 year: 1997 end-page: 1854 ident: CR29 article-title: Effect of intravenous lactated Ringer's solution infusion on the circulating lactate concentration: part 3. Results of a prospective, randomized, double-blind, placebo-controlled trial publication-title: Crit Care Med doi: 10.1097/00003246-199711000-00024 – volume: 6 start-page: 3332 issue: 42 year: 2017 end-page: 3336 ident: CR33 article-title: Study of serum magnesium levels in critically ill patients publication-title: JEMDS doi: 10.14260/Jemds/2017/722 – ident: CR13 – volume: 31 start-page: 187 issue: 3 year: 2016 end-page: 192 ident: CR8 article-title: The association between admission magnesium concentrations and lactic acidosis in critical illness publication-title: J Intensive Care Med doi: 10.1177/0885066614530659 – volume: 16 start-page: 331 issue: 1 year: 2018 ident: CR35 article-title: Early goal directed and lactate-guided therapy in adult patients with severe sepsis and septic shock: a meta-analysis of randomized controlled trials publication-title: J Transl Med doi: 10.1186/s12967-018-1700-7 – volume: 24 start-page: 571 issue: 5 year: 2014 end-page: 577 ident: CR30 article-title: Effects of rapid intravenous 100% L-isomer lactated Ringer's administration on plasma lactate concentrations in healthy dogs publication-title: J Vet Emerg Crit Care (San Antonio) doi: 10.1111/vec.12213 – volume: 50 start-page: 162 issue: 2 year: 2018 end-page: 166 ident: CR34 article-title: Effect of dexmedetomidine on lactate clearance in patients with septic shock: a subanalysis of a multicenter randomized controlled trial publication-title: Shock doi: 10.1097/SHK.0000000000001055 – ident: CR24 – volume: 3 start-page: 3 issue: 1 year: 2013 ident: CR19 article-title: Lactate clearance for death prediction in severe sepsis or septic shock patients during the first 24 hours in intensive care unit: an observational study publication-title: Ann Intensive Care doi: 10.1186/2110-5820-3-3 – volume: 14 start-page: 92 issue: 2 year: 2000 end-page: 95 ident: CR22 article-title: Determination of iron, copper, zinc, magnesium and selenium in plasma and erythrocytes in neurosurgical patients publication-title: J Trace Elem Med Biol doi: 10.1016/S0946-672X(00)80037-1 – volume: 39 start-page: 165 issue: 2 year: 2013 ident: 2788_CR21 publication-title: Intensive Care Med doi: 10.1007/s00134-012-2769-8 – volume: 109 start-page: 453 issue: 7 year: 2016 ident: 2788_CR4 publication-title: QJM doi: 10.1093/qjmed/hcw048 – volume: 32 start-page: 296 issue: 3 year: 2017 ident: 2788_CR14 publication-title: Nutr Clin Pract doi: 10.1177/0884533617695243 – volume: 16 start-page: 464 year: 2017 ident: 2788_CR1 publication-title: EXCLI J – volume: 25 start-page: 1851 issue: 11 year: 1997 ident: 2788_CR29 publication-title: Crit Care Med doi: 10.1097/00003246-199711000-00024 – volume: 17 start-page: 37 issue: 1 year: 2016 ident: 2788_CR9 publication-title: JIACM – volume: 50 start-page: 545 issue: 5 year: 2018 ident: 2788_CR20 publication-title: Shock doi: 10.1097/SHK.0000000000001128 – volume: 46 start-page: 1747 issue: 11 year: 2018 ident: 2788_CR27 publication-title: Crit Care Med doi: 10.1097/CCM.0000000000003311 – volume: 19 start-page: 379 issue: 7 year: 2015 ident: 2788_CR5 publication-title: Indian J Crit Care Med doi: 10.4103/0972-5229.160272 – volume: 14 start-page: 92 issue: 2 year: 2000 ident: 2788_CR22 publication-title: J Trace Elem Med Biol doi: 10.1016/S0946-672X(00)80037-1 – ident: 2788_CR13 doi: 10.1177/0885066618777431 – volume: 80 start-page: 100 year: 1961 ident: 2788_CR23 publication-title: Biochem J doi: 10.1042/bj0800099 – volume: 3 start-page: 3 issue: 1 year: 2013 ident: 2788_CR19 publication-title: Ann Intensive Care doi: 10.1186/2110-5820-3-3 – volume: 37 start-page: 179 year: 2017 ident: 2788_CR15 publication-title: J Crit Care doi: 10.1016/j.jcrc.2016.09.023 – volume: 4 start-page: 4032 issue: 67 year: 2017 ident: 2788_CR12 publication-title: JEBMH doi: 10.18410/jebmh/2017/805 – volume: 318 start-page: 1233 issue: 13 year: 2017 ident: 2788_CR31 publication-title: JAMA doi: 10.1001/jama.2017.10913 – volume: 16 start-page: 331 issue: 1 year: 2018 ident: 2788_CR35 publication-title: J Transl Med doi: 10.1186/s12967-018-1700-7 – volume: 7 start-page: 911 issue: 12 year: 2015 ident: 2788_CR7 publication-title: J Clin Med Res doi: 10.14740/jocmr2351w – volume: 6 start-page: 3332 issue: 42 year: 2017 ident: 2788_CR33 publication-title: JEMDS doi: 10.14260/Jemds/2017/722 – volume: 48 start-page: 191 year: 2018 ident: 2788_CR18 publication-title: J Crit Care doi: 10.1016/j.jcrc.2018.08.035 – ident: 2788_CR24 doi: 10.5772/25925 – volume: 50 start-page: 162 issue: 2 year: 2018 ident: 2788_CR34 publication-title: Shock doi: 10.1097/SHK.0000000000001055 – volume: 25 start-page: 576 issue: 4 year: 2010 ident: 2788_CR17 publication-title: J Crit Care doi: 10.1016/j.jcrc.2010.03.003 – volume: 30 start-page: 1349 issue: 6 year: 2015 ident: 2788_CR3 publication-title: J Crit Care doi: 10.1016/j.jcrc.2015.07.029 – volume: 10 issue: 12 year: 2015 ident: 2788_CR28 publication-title: PLoS One doi: 10.1371/journal.pone.0145181 – volume: 47 start-page: 288 issue: 3 year: 2017 ident: 2788_CR10 publication-title: Shock doi: 10.1097/SHK.0000000000000769 – volume: 8 start-page: 184 issue: 3 year: 2017 ident: 2788_CR26 publication-title: World J Emerg Med doi: 10.5847/wjem.j.1920-8642.2017.03.004 – volume: 24 start-page: 571 issue: 5 year: 2014 ident: 2788_CR30 publication-title: J Vet Emerg Crit Care (San Antonio) doi: 10.1111/vec.12213 – volume: 45 start-page: 82 issue: 1 year: 2018 ident: 2788_CR32 publication-title: Intensive Care Medicine doi: 10.1007/s00134-018-5213-x – ident: 2788_CR6 – volume: 22 start-page: A228 issue: 1 year: 1994 ident: 2788_CR25 publication-title: Crit Care Med doi: 10.1097/00003246-199401000-00438 – volume: 6 start-page: 21 issue: 1 year: 2018 ident: 2788_CR2 publication-title: J Intensive Care doi: 10.1186/s40560-018-0291-y – volume: 31 start-page: 187 issue: 3 year: 2016 ident: 2788_CR8 publication-title: J Intensive Care Med doi: 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| SubjectTerms | Biomedical and Life Sciences Biomedicine Clinical Trial Intravenous administration Lactic acid Magnesium sulfate Pharmacology/Toxicology Sepsis Supplements |
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| Title | Effect of magnesium supplementation on lactate clearance in critically ill patients with severe sepsis: a randomized clinical trial |
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