Aberrant Lipid Metabolism in Macrophages Is Associated with Granuloma Formation in Sarcoidosis

• Published in: American journal of respiratory and critical care medicine Vol. 209; no. 9; pp. 1152 - 1164
• Main Authors: Lim, Clarice X., Redl, Anna, Kleissl, Lisa, Pandey, Ram Vinay, Mayerhofer, Carolina, El Jammal, Thomas, Mazic, Mario, Gonzales, Karine, Sukhbaatar, Nyamdelger, Krausgruber, Thomas, Bock, Christoph, Hengstschläger, Markus, Calender, Alain, Pacheco, Yves, Stary, Georg, Weichhart, Thomas
• Format: Journal Article
• Language: English
• Published: United States American Thoracic Society 01.05.2024
• Subjects: Adult; Animals; Cholesterol; Disease Models, Animal; Female; Granuloma - metabolism; Granulomas; Humans; Lipid Metabolism; Lipids; Macrophages - metabolism; Male; Metabolism; Mice; Middle Aged; Sarcoidosis; Sarcoidosis - metabolism; non-Löfgren’s; macrophages; sarcoidosis; lipid-laden; granuloma

Chronic sarcoidosis is a complex granulomatous disease with limited treatment options that can progress over time. Understanding the molecular pathways contributing to disease would aid in new therapeutic development. To understand whether macrophages from patients with nonresolving chronic sarcoido...