Population Pharmacokinetics of Mycophenolic Acid Co-Administered with Tacrolimus in Corticosteroid-Free Adult Kidney Transplant Patients

• Published in: Clinical pharmacokinetics Vol. 58; no. 11; pp. 1483 - 1495
• Main Authors: Rong, Yan, Mayo, Patrick, Ensom, Mary H. H., Kiang, Tony K. L.
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.11.2019; Springer Nature B.V
• Subjects: Acids; Age; Chromatography; Creatinine; Cytomegalovirus; Drug dosages; Internal Medicine; Kidney transplants; Medicine; Medicine & Public Health; Metabolites; Oral administration; Original Research Article; Patients; Pharmacokinetics; Pharmacology/Toxicology; Pharmacotherapy; Software

Background and Objective Mycophenolic acid is commonly prescribed to adult kidney transplant recipients. Mycophenolic acid is extensively metabolized to mycophenolic acid-glucuronide (major metabolite) and mycophenolic acid-acyl-glucuronide (minor metabolite). We hypothesized that (1) adult kidney t...