Mosaic composition of RIP1–RIP3 signalling hub and its role in regulating cell death

• Published in: Nature cell biology Vol. 24; no. 4; pp. 471 - 482
• Main Authors: Chen, Xin, Zhu, Rongfeng, Zhong, Jinjin, Ying, Yongfa, Wang, Wenxin, Cao, Yating, Cai, Hanyi, Li, Xiang, Shuai, Jianwei, Han, Jiahuai
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.04.2022; Nature Publishing Group
• Subjects: 14/19; 14/28; 14/3; 631/1647/328/2238; 631/80/82/2344; 631/80/86; 96/95; Amyloid; Apoptosis; Apoptosis - physiology; Biomedical and Life Sciences; Cancer Research; Cell Biology; Cell Death; Cellular structure; Developmental Biology; Humans; Life Sciences; Mortality; Mosaics; Necroptosis; Necrosis - metabolism; Oligomerization; Oligomers; Protein Kinases - metabolism; Receptor-Interacting Protein Serine-Threonine Kinases - genetics; Receptor-Interacting Protein Serine-Threonine Kinases - metabolism; Signal Transduction; Signaling; Stem Cells

RIP1 and RIP3, cell death mediators, form fibrous amyloids. How RIP1/RIP3 amyloidal oligomers assemble functional necrosomes and control cell death is largely unknown. Here we use super-resolution microscopy to directly visualize cellular necrosomes as mosaics of RIP1 and RIP3 oligomers. The small (...