Macrophage migration inhibitory factor polymorphism (rs755622) in alopecia areata: a possible role in disease prevention

• Published in: Archives of Dermatological Research Vol. 311; no. 8; pp. 589 - 594
• Main Authors: Rajabi, Fateme, Amoli, Mahsa M., Robati, Reza M., Almasi-nasrabadi, Mina, Jabalameli, Navid
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2019; Springer Nature B.V
• Subjects: Adolescent; Adult; Aged; Alleles; Alopecia; Alopecia Areata - genetics; Alopecia Areata - immunology; Alopecia Areata - prevention & control; Autoimmune diseases; Autoimmunity - genetics; Baldness; Case-Control Studies; Cytokines; Dermatology; Female; Follicles; Gene polymorphism; Genetic Predisposition to Disease; Genotype; Hair; Hair Follicle - immunology; Hair Follicle - pathology; Hair loss; Healthy Volunteers; Humans; Immune privilege; Immune Privilege - genetics; Inflammation; Intramolecular Oxidoreductases - genetics; Intramolecular Oxidoreductases - immunology; Leukocyte migration; Macrophage migration inhibitory factor; Macrophage Migration-Inhibitory Factors - genetics; Macrophage Migration-Inhibitory Factors - immunology; Male; Medicine; Medicine & Public Health; Middle Aged; Natural killer cells; Original Paper; Polymorphism, Single Nucleotide; Preservation; Scalp; Transcription; Young Adult; Autoimmunity; Genetic association study; Hair follicle; Immune privilege; Natural killer cells

Alopecia areata (AA) is an organ-specific autoimmune disease that targets the bulb of the hair follicles and results in non-scarring hair loss that can range from patchy lesions to involvement of the entire scalp. AA develops when the hair follicles lose their physiologic state of immune privilege....