Role of Na+/K+-ATPase in ischemic stroke: in-depth perspectives from physiology to pharmacology

• Published in: Journal of molecular medicine (Berlin, Germany) Vol. 100; no. 3; pp. 395 - 410
• Main Authors: Zhu, Mengyuan, Sun, Haijian, Cao, Lei, Wu, Zhiyuan, Leng, Bin, Bian, Jinsong
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.03.2022; Springer Nature B.V
• Subjects: Adenosine triphosphate; Autophagy; Biomedical and Life Sciences; Biomedicine; Blood coagulation; Blood flow; Brain research; Calcium signalling; Clinical trials; Excitability; Excitotoxicity; Homeostasis; Human Genetics; Inflammation; Inositol 1,4,5-trisphosphate receptors; Internal Medicine; Ischemia; Kinases; MAP kinase; Medicine; Molecular Medicine; Na+/K+-exchanging ATPase; Oxidative stress; Pharmacology; Phosphorylation; Physiology; Proteins; Review; Roles; Stroke; Signal transducer; Oxidative stress; Na; ATPase (NKA); Inflammation; K; Ischemic stroke; Autophagy; Na+/K+-ATPase (NKA)

Na + /K + -ATPase (NKA) is a large transmembrane protein expressed in all cells. It is well studied for its ion exchanging function, which is indispensable for the maintenance of electrochemical gradients across the plasma membrane and herein neuronal excitability. The widely recognized pump functio...