Derivatives of 3, 4, 5-Trimethoxycinnamic Acid Ameliorate Stress-Induced Anxiety in Mice and Rats

• Published in: Molecular neurobiology Vol. 60; no. 5; pp. 2737 - 2748
• Main Authors: Hong, Eunchong, Min, Hyun Kyu, Lim, Heena, Gu, Sun Mi, Jabborov, Abdulaziz, Yayeh, Taddesse, Kim, Mijin, Park, Woo-Kyu, Jung, Jae-Chul, Yun, Jaesuk, Oh, Seikwan
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.05.2023; Springer Nature B.V
• Subjects: Amygdala; Animals; Anti-Anxiety Agents - pharmacology; Anti-Anxiety Agents - therapeutic use; Anxiety; Anxiety - drug therapy; Biomedical and Life Sciences; Biomedicine; Cell Biology; Dopamine; Extracellular signal-regulated kinase; Immobilization; Mice; Neurobiology; Neurology; Neurons; Neurosciences; Pheochromocytoma cells; Protein expression; Rats; Serotonin receptors; Stress; Tyrosine 3-monooxygenase; TMCA derivatives; Tyrosine hydroxylase; Stress

Stress is an overwhelming problem associated with neuronal damage leading to anxiety and depression. The compound 3, 4, 5-trimethoxycinnamic acid (TMCA) has shown anti-stress effects; however, its derivatives remained unknown for their anxiolytic properties. Here, therefore, we investigated derivati...