Clinical and Immunological Features of 96 Moroccan Children with SCID Phenotype: Two Decades’ Experience

• Published in: Journal of clinical immunology Vol. 41; no. 3; pp. 631 - 638
• Main Authors: Benhsaien, Ibtihal, Ailal, Fatima, El Bakkouri, Jalila, Jeddane, Leïla, Ouair, Hind, Admou, Brahim, Bouskraoui, Mohamed, Hbibi, Mohamed, Hida, Mustapha, Amenzoui, Naïma, Jouhadi, Zineb, El Hafidi, Naïma, Rada, Nouredine, Benajiba, Noufissa, Abilkassem, Rachid, Badou, Abdallah, Bousfiha, Ahmed Aziz
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2021; Springer Nature B.V
• Subjects: Alleles; Autografts; Biomarkers; Biomedical and Life Sciences; Biomedicine; Candidiasis; Children; Chronic infection; Consanguinity; Cross-Sectional Studies; Diagnosis; Diagnosis, Differential; Diarrhea; Disease Management; Disease Susceptibility; Epidemiology; Genetic Predisposition to Disease; Genotype; Genotype & phenotype; Hematopoietic stem cells; Humans; Immunology; Infectious Diseases; Inheritance Patterns; Internal Medicine; Lymphocytes T; Lymphopenia; Medical Microbiology; Morocco - epidemiology; Original Article; Patients; Phenotype; Phenotypes; Primary immunodeficiencies; Public Health Surveillance; Recurrent infection; Respiratory tract diseases; Severe combined immunodeficiency; Severe Combined Immunodeficiency - diagnosis; Severe Combined Immunodeficiency - epidemiology; Severe Combined Immunodeficiency - etiology; Stem cell transplantation; Morocco; epidemiology; Severe combined immunodeficiency; Morocco; immunophenotype

Severe combined immunodeficiency (SCID) is a heterogeneous group of primary immunodeficiency diseases (PIDs) characterized by a lack of autologous T lymphocytes. This severe PID is rare, but has a higher prevalence in populations with high rates of consanguinity. The epidemiological, clinical, and i...