Antidepressants and driver impairment: empirical evidence from a standard on-the-road test

• Published in: The journal of clinical psychiatry Vol. 64; no. 1; p. 20
• Main Author: Ramaekers, Johannes G
• Format: Journal Article
• Language: English
• Published: United States 01.01.2003
• Subjects: Accidents, Traffic - statistics & numerical data; Adult; Aged; Alcohol Drinking - blood; Antidepressive Agents - adverse effects; Antidepressive Agents - therapeutic use; Automobile Driver Examination - statistics & numerical data; Automobile Driving - psychology; Benzodiazepines - adverse effects; Benzodiazepines - therapeutic use; Clinical Trials as Topic; Cross-Over Studies; Depressive Disorder - drug therapy; Depressive Disorder - psychology; Dose-Response Relationship, Drug; Double-Blind Method; Drug Therapy, Combination; Ethanol - blood; Humans; Middle Aged; Psychomotor Performance - drug effects

The current review summarizes the major results from all published studies from 1983 to 2000 (9 double-blind, crossover, placebo-controlled studies in healthy volunteers and 1 double-blind, baseline-controlled study in patients) that have determined the effects of antidepressants on actual driving p...