Benchmark of site- and structure-specific quantitative tissue N-glycoproteomics for discovery of potential N-glycoprotein markers: a case study of pancreatic cancer

• Published in: Glycoconjugate journal Vol. 38; no. 2; pp. 213 - 231
• Main Authors: Lu, Haoran, Xiao, Kaijie, Tian, Zhixin
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.04.2021; Springer Nature B.V
• Subjects: Antibiotics; Benchmarking; Biochemistry; Biomarkers, Tumor - metabolism; Biomedical and Life Sciences; Databases, Protein; Gastrointestinal tract; Glycopeptides; Glycoproteins; Glycoproteins - analysis; Glycoproteins - chemistry; Glycoproteins - metabolism; Humans; Isotope Labeling; Life Sciences; Mass Spectrometry and the Analysis of Glycoconjugates; Mass spectroscopy; Monosaccharides; Original Article; Pancreatic cancer; Pancreatic Neoplasms - metabolism; Pathology; Proteomics - methods; Search Engine; Tandem Mass Spectrometry - methods; Biomarkers; Quantitative N-glycoproteomics; Pancreatic cancer tissues; N-glycosylation; Differentially expressed intact N-glycopeptides

Pancreatic cancer is a highly malignant tumor of the digestive tract that is difficult to diagnose and treat. It is more common in developed countries and has become one of the main causes of death in some countries and regions. Currently, pancreatic cancer generally has a poor prognosis, partly due...