Myeloid neoplasms with features intermediate between primary myelofibrosis and chronic myelomonocytic leukemia

• Published in: Modern pathology Vol. 31; no. 3; pp. 429 - 441
• Main Authors: Chapman, Jennifer, Geyer, Julia T, Khanlari, Mahsa, Moul, Adrienne, Casas, Carmen, Connor, Scot T, Fan, Yao-Shan, Watts, Justin M, Swords, Ronan T, Vega, Francisco, Orazi, Attilio
• Format: Journal Article
• Language: English
• Published: New York Nature Publishing Group US 01.03.2018; Elsevier Limited
• Subjects: 13/51; 13/56; 38/39; 631/67/1990/1673; 692/699/1541/1990/1673; 96/63; Aged; Chronic myelomonocytic leukemia; Diagnosis, Differential; Dioxygenases; Disease Progression; DNA-Binding Proteins - genetics; Dysplasia; Female; Fibrosis; Geriatrics; GTP Phosphohydrolases - genetics; Humans; Janus kinase 2; Janus Kinase 2 - genetics; Laboratory Medicine; Leukemia; Leukemia, Myelomonocytic, Chronic - genetics; Leukemia, Myelomonocytic, Chronic - pathology; Male; Medical innovations; Medicine; Medicine & Public Health; Megakaryocytes; Membrane Proteins - genetics; Middle Aged; Monocytosis; Mutation; Myelodysplastic syndrome; Myelofibrosis; Myelomonocytic leukemia; original-article; Osteosclerosis; Pathology; Primary Myelofibrosis - genetics; Primary Myelofibrosis - pathology; Proto-Oncogene Proteins - genetics; Proto-Oncogene Proteins p21(ras) - genetics; Receptors, Thrombopoietin - genetics; Reclassification; Repressor Proteins - genetics; Serine-Arginine Splicing Factors - genetics; Taxonomy; Tumors
• ISSN: 0893-3952; 1530-0285; 1530-0285
• DOI: 10.1038/modpathol.2017.148

Monocytosis can develop during disease course in primary myelofibrosis simulating that seen in chronic myelomonocytic leukemia, and should not lead to disease reclassification. In contrast, at presentation, rare cases have clinical, morphologic, and molecular genetic features truly intermediate betw...