Combination of IFN-gamma with STING agonist and PD-1 immune checkpoint blockade: a potential immunotherapy for gastric cancer

• Published in: Medical oncology (Northwood, London, England) Vol. 41; no. 5; p. 110
• Main Authors: Hosseinzadeh, Shahnaz, Imani, Mahsa, Pourfarzi, Farhad, Jafari, Narjes, AbedianKenari, Saeid, Safarzadeh, Elham
• Format: Journal Article
• Language: English
• Published: New York Springer US 09.04.2024; Springer Nature B.V
• Subjects: Agonists; Apoptosis; Cancer therapies; Gastric cancer; Hematology; Humans; Immune Checkpoint Inhibitors - pharmacology; Immune Checkpoint Inhibitors - therapeutic use; Immunotherapy; Interferon-gamma; Internal Medicine; Leukocytes, Mononuclear; Medicine; Medicine & Public Health; Nucleotidyltransferases; Oncology; Original Paper; Pathology; Programmed Cell Death 1 Receptor; Stomach Neoplasms - drug therapy; cGAS; STING; IFN-gamma; Gastric cancer; PBMC; Immunotherapy

Suppression of the cGAS-STING pathway is an immune escape mechanism in cancer cells. The critical role of this pathway in gastric cancer (GC) is not fully understood. Herein, we evaluated the effect of the interferon-gamma (IFN-gamma), STING agonist, PD-1 immune checkpoint blockade, and their combin...