Aristolochic acid-containing Chinese herbal medicine and upper urinary tract urothelial carcinoma in Taiwan: a narrative review

• Published in: World journal of urology Vol. 41; no. 4; pp. 899 - 907
• Main Authors: Dickman, Kathleen G., Chen, Chung-Hsin, Grollman, Arthur P., Pu, Yeong-Shiau
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2023; Springer Nature B.V
• Subjects: Aristolochia; Aristolochic acid; Aristolochic Acids - adverse effects; Aristolochic Acids - analysis; Biomarkers; Bladder cancer; Carcinogens; Carcinoma, Transitional Cell - chemically induced; Carcinoma, Transitional Cell - epidemiology; Carcinoma, Transitional Cell - genetics; Conserved sequence; Deoxyadenosine; DNA adducts; DNA Adducts - adverse effects; Drugs, Chinese Herbal - adverse effects; Epidemiology; Female; Herbal medicine; Humans; Kidney Neoplasms - chemically induced; Kidney Neoplasms - epidemiology; Kidney Neoplasms - genetics; Medicine; Medicine & Public Health; Mutation; Nephrectomy; Nephrology; Nephropathy; Nucleotide sequence; Oncology; Renal failure; Renal function; Taiwan - epidemiology; Topic Paper; Trinucleotide repeats; Ureteral Neoplasms - chemically induced; Ureteral Neoplasms - epidemiology; Urinary Bladder Neoplasms; Urinary Tract; Urogenital system; Urology; Urothelial carcinoma; Taiwan; Ureteral cancer; DNA adduct; Renal pelvic cancer; Nephropathy; Mass spectrometry; Aristolochia

Purpose The high incidence of upper urinary tract urothelial carcinoma (UTUC) in Taiwan is largely due to exposure to aristolochic acid (AA), a principal component of Aristolochia -based herbal medicines. Here we systematically review the molecular epidemiology, clinical presentation and biomarkers...