Blood-Related Toxicity after Traumatic Brain Injury: Potential Targets for Neuroprotection

• Published in: Molecular neurobiology Vol. 57; no. 1; pp. 159 - 178
• Main Authors: Robicsek, Steven A., Bhattacharya, Ayon, Rabai, Ferenc, Shukla, Krunal, Doré, Sylvain
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.01.2020; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; Blood; Cell Biology; Cell death; Edema; Ferritin; Haptoglobin; Heme; Hemin; Hemoglobin; Hemopexin; Immune clearance; Immune response; Inflammation; Lipid peroxidation; Metabolites; Morbidity; Mortality; Neurobiology; Neurology; Neuroprotection; Neurosciences; Oxidants; Oxygenase; Pain perception; Reactive oxygen species; Therapeutic applications; Toxicity; Traumatic brain injury; Hemopexin; CD163; Iron; CD36; LRP1; Ferritin

Emergency visits, hospitalizations, and deaths due to traumatic brain injury (TBI) have increased significantly over the past few decades. While the primary early brain trauma is highly deleterious to the brain, the secondary injury post-TBI is postulated to significantly impact mortality. The prese...