PKCβII phosphorylates ACSL4 to amplify lipid peroxidation to induce ferroptosis - Zhang, Hai-Liang; Hu, Bing-Xin; Li, Zhi-Ling; Du, Tian; Shan, Jia-Lu; Ye, Zhi-Peng; Peng, Xiao-Dan; Li, Xuan; Huang, Yun; Zhu, Xian-Ying; Chen, Yu-Hong; Feng, Gong-Kan; et al. (Nature cell biology, 2022)
Keywords: 13/95; 631/45/607/275; 631/67/1059/2325; 631/80/82; 631/92/287/1192; Accumulation; Amplification; Animals; Attenuation; Biomedical and Life Sciences; Biosynthesis; Cancer immunotherapy; Cancer Research; Cell Biology; Cell Line, Tumor; Coenzyme A Ligases - metabolism; CRISPR; CRISPR-Cas Systems - genetics; Developmental Biology; Enzyme inhibitors; Fatty acids; Ferroptosis; Ferroptosis - physiology; Gene Knockout Techniques; Genomes; Humans; Immunotherapy; Immunotherapy - methods; Kinases; Life Sciences; Lipid peroxidation; Lipid Peroxidation - physiology; Lipids; Medical treatment; Mice; Mice, Inbred BALB C; Mice, Inbred C57BL; Neoplasms - therapy; Peroxidation; Peroxides; Phosphorylation; Polyunsaturated fatty acids; Protein kinase C; Protein Kinase C beta - genetics; Protein Kinase C beta - metabolism; Screening; Stem Cells