Andrographolide enhances hippocampal BDNF signaling and suppresses neuronal apoptosis, astroglial activation, neuroinflammation, and spatial memory deficits in a rat model of chronic cerebral hypoperfusion

• Published in: Naunyn-Schmiedeberg's archives of pharmacology Vol. 392; no. 10; pp. 1277 - 1284
• Main Authors: Wang, Da-Peng, Yin, Hang, Lin, Qi, Fang, Shu-Ping, Shen, Jian-Hua, Wu, Yi-Fang, Su, Shao-Hua, Hai, Jian
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.10.2019; Springer Nature B.V
• Subjects: Animal memory; Animal models; Anti-inflammatory agents; Apoptosis; Biomedical and Life Sciences; Biomedicine; Brain-derived neurotrophic factor; Caspase; Caspase-3; Cerebral blood flow; Cognitive ability; Glial fibrillary acidic protein; Hippocampus; Inflammation; Interleukin 1; Ischemia; Learning; Memory; Neurodegeneration; Neuroprotection; Neuroprotective agents; Neurosciences; Original Article; Pharmacology/Toxicology; Proteinase; Proteinase 3; Spatial discrimination learning; Spatial memory; Traumatic brain injury; TrkB receptors; Tumor necrosis factor-TNF; Western blotting; BDNF signaling; Chronic cerebral hypoperfusion; Astrocyte; Andrographolide; Cognitive impairment

Andrographolide is a medical herbal compound with documented anti-inflammatory activity and therapeutic efficacy in animal models of Alzheimer’s disease, traumatic brain injury, and ischemic stroke. The present study examined the potential therapeutic effects of andrographolide on chronic cerebral h...