Andrographolide enhances hippocampal BDNF signaling and suppresses neuronal apoptosis, astroglial activation, neuroinflammation, and spatial memory deficits in a rat model of chronic cerebral hypoperfusion - Wang, Da-Peng; Yin, Hang; Lin, Qi; Fang, Shu-Ping; Shen, Jian-Hua; Wu, Yi-Fang; Su, Shao-Hua; Hai, Jian (Naunyn-Schmiedeberg's archives of pharmacology, 2019)
Keywords: Animal memory; Animal models; Anti-inflammatory agents; Apoptosis; Biomedical and Life Sciences; Biomedicine; Brain-derived neurotrophic factor; Caspase; Caspase-3; Cerebral blood flow; Cognitive ability; Glial fibrillary acidic protein; Hippocampus; Inflammation; Interleukin 1; Ischemia; Learning; Memory; Neurodegeneration; Neuroprotection; Neuroprotective agents; Neurosciences; Original Article; Pharmacology/Toxicology; Proteinase; Proteinase 3; Spatial discrimination learning; Spatial memory; Traumatic brain injury; TrkB receptors; Tumor necrosis factor-TNF; Western blotting; BDNF signaling; Chronic cerebral hypoperfusion; Astrocyte; Andrographolide; Cognitive impairment