Repositioning of Disulfiram in Association with Vancomycin Against Enterococcus spp. MDR and XDR

• Published in: Current microbiology Vol. 79; no. 5; p. 137
• Main Authors: Serafin, Marissa B., Foletto, Vitória S., da Rosa, Taciéli F., Bottega, Angelita, Viana, Altevir Rossato, Franco, Laísa Nunes, de Lima Marion, Sara, da Mota, Augusto Dias, de Paula, Bruno Rafael, Krause, Luciana Maria Fontanari, Finatto, Luis Junior, Hörner, Manfredo, Hörner, Rosmari
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.05.2022; Springer Nature B.V
• Subjects: American Type Culture Collection; Antibacterial activity; Antibiotic resistance; Antibiotics; Biomedical and Life Sciences; Biotechnology; Cell culture; Clinical isolates; Cytotoxicity; Disulfiram; Disulfiram - pharmacology; Drug Repositioning; Drug resistance; Enterococcus; Life Sciences; Microbial Sensitivity Tests; Microbiology; Microorganisms; Minimum inhibitory concentration; Morbidity; Multidrug resistance; Nosocomial infection; Nosocomial infections; Short Communication; Strains (organisms); Synergism; Toxicity testing; Vancomycin; Vancomycin - pharmacology

The identification of molecules that exhibit potent antibacterial activity and are capable of circumventing resistance mechanisms is an unmet need. The repositioning of approved drugs is considered an advantageous alternative in this case, and has gained prominence. In addition, drug synergism can r...