Mycobacterium tuberculosis controls host innate immune activation through cyclopropane modification of a glycolipid effector molecule

• Published in: The Journal of experimental medicine Vol. 201; no. 4; pp. 535 - 543
• Main Authors: Rao, Vivek, Fujiwara, Nagatoshi, Porcelli, Steven A, Glickman, Michael S
• Format: Journal Article
• Language: English
• Published: United States The Rockefeller University Press 21.02.2005
• Subjects: Animals; Cell Line; Colony Count, Microbial; Cord Factors - chemistry; Cord Factors - isolation & purification; Cord Factors - metabolism; Cyclopropanes - chemistry; Immunity, Innate; Interleukin-6 - biosynthesis; Macrophage Activation; Macrophages - immunology; Macrophages - microbiology; Methyltransferases - deficiency; Methyltransferases - genetics; Methyltransferases - metabolism; Mice; Mice, Inbred C57BL; Mice, Knockout; Mutation; Mycobacterium tuberculosis; Mycobacterium tuberculosis - chemistry; Mycobacterium tuberculosis - genetics; Mycobacterium tuberculosis - pathogenicity; Tuberculosis, Pulmonary - etiology; Tuberculosis, Pulmonary - immunology; Tumor Necrosis Factor-alpha - biosynthesis; Tumor Necrosis Factor-alpha - deficiency; Tumor Necrosis Factor-alpha - genetics

Mycobacterium tuberculosis (Mtb) infection remains a global health crisis. Recent genetic evidence implicates specific cell envelope lipids in Mtb pathogenesis, but it is unclear whether these cell envelope compounds affect pathogenesis through a structural role in the cell wall or as pathogenesis e...