Molecular characterization of depression trait and state

• Published in: Molecular psychiatry Vol. 27; no. 2; pp. 1083 - 1094
• Main Authors: Shukla, Rammohan, Newton, Dwight F., Sumitomo, Akiko, Zare, Habil, Mccullumsmith, Robert, Lewis, David A., Tomoda, Toshifumi, Sibille, Etienne
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.02.2022; Nature Publishing Group
• Subjects: 38; 38/91; 631/1647; 631/378; Autopsies; Bayes Theorem; Bayesian analysis; Behavioral Sciences; Bioenergetics; Biological Psychology; Brain research; Case-Control Studies; Cortex (cingulate); Corticotropin-releasing hormone; Depression - genetics; Depressive Disorder, Major - drug therapy; Dopamine receptors; Drug discovery; Gene expression; Gyrus Cinguli - metabolism; Humans; Immune response; Interneurons; Medicine; Medicine & Public Health; Mental depression; Neurosciences; Neurotransmission; Pharmacotherapy; Psychiatry; R&D; Remission; Remission (Medicine); Research & development; Somatostatin; Toxicology; Transcriptomics; Vasoactive agents; γ-Aminobutyric acid

Major depressive disorder (MDD) is a brain disorder often characterized by recurrent episode and remission phases. The molecular correlates of MDD have been investigated in case-control comparisons, but the biological alterations associated with illness trait (regardless of clinical phase) or curren...