Effects of Resveratrol on Tight Junction Proteins and the Notch1 Pathway in an HT-29 Cell Model of Inflammation Induced by Lipopolysaccharide

• Published in: Inflammation Vol. 45; no. 6; pp. 2449 - 2464
• Main Authors: Luo, Yihua, Yu, Xueyan, Zhao, Peizhuang, Huang, Jun, Huang, Xue
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.12.2022; Springer Nature B.V
• Subjects: Biomedical and Life Sciences; Biomedicine; Epithelium; Immunology; Inflammation; Inflammatory bowel diseases; Interleukin 6; Internal Medicine; Intestine; Lipopolysaccharides; Notch1 protein; Original Article; Pathology; Pharmacology/Toxicology; Proteins; Resveratrol; Rheumatology; Tumor necrosis factor-TNF; Tumor necrosis factor-α; Ulcerative colitis; Zonula occludens-1 protein; Notch1 pathway; Tight junction protein; HT-29; Resveratrol; Ulcerative colitis

Ulcerative colitis (UC) is closely associated with disruption of intestinal epithelial tight junction proteins. A variety of studies have confirmed that resveratrol (RSV), a natural polyphenolic compound, has a potential anti-inflammatory effect and can regulate the expression of tight junction prot...