Relationship between visceral adipose tissue and genetic mutations (VHL and KDM5C) in clear cell renal cell carcinoma

• Published in: Radiologia medica Vol. 126; no. 5; pp. 645 - 651
• Main Authors: Greco, Federico, Mallio, Carlo Augusto
• Format: Journal Article
• Language: English
• Published: Milan Springer Milan 01.05.2021; Springer Nature B.V
• Subjects: Abdominal Radiology; Adipose tissue; Adult; Aged; Aged, 80 and over; Carcinoma, Renal Cell - diagnostic imaging; Carcinoma, Renal Cell - genetics; Diagnostic Radiology; Histone Demethylases - genetics; Humans; Imaging; Interventional Radiology; Intra-Abdominal Fat; Kidney cancer; Kidney Neoplasms - diagnostic imaging; Kidney Neoplasms - genetics; Male; Medicine; Medicine & Public Health; Middle Aged; Mutation; Neuroradiology; Radiology; Retrospective Studies; Tomography, X-Ray Computed; Ultrasound; Von Hippel-Lindau Tumor Suppressor Protein - genetics; Adipocyte; CT; KDM5C; Clear cell renal cell carcinoma; Visceral adipose tissue; VHL
• DOI: 10.1007/s11547-020-01310-y
• ISSN: 0033-8362; 1826-6983

Background The sequencing of the renal cell carcinoma (RCC) genome has detected several mutations with prognostic meaning. The association between visceral adipose tissue (VAT) and clear cell renal cell carcinoma (ccRCC) is well known. The relationship among abdominal adipose tissue distribution and ccRCC-VHL and KDM5C genetic mutations is, to the knowledge of the authors, not known. Methods In this retrospective study, we enrolled 97 Caucasian male patients divided into three groups: the control group ( n  = 35), the ccRCC-VHL group ( n  = 52) composed of ccRCC patients with VHL mutations and ccRCC-KDM5C group ( n  = 10) composed of ccRCC patients with KDM5C mutation. Total adipose tissue (TAT) area, VAT area and subcutaneous adipose tissue (SAT) area were measured in the groups. VAT/SAT ratio was calculated for each subject. Results Statistically significant differences between ccRCC-KDM5C group and ccRCC-VHL group were obtained for TAT area ( p  < 0.05), VAT area ( p  < 0.05) and VAT/SAT ratio ( p  < 0.05); between ccRCC-VHL group and control group for TAT area ( p  < 0.001) and VAT area ( p  < 0.01); and between ccRCC-KDM5C group and control group for TAT area ( p  < 0.0001), VAT area ( p  < 0.0001) and SAT area ( p  < 0.01). Conclusions This study demonstrates for the first time an increased amount of TAT, especially VAT, in the ccRCC-VHL and ccRCC-KDM5C groups. The effect was greater for the ccRCC-KDM5C group.