Placental insufficiency contributes to fatty acid metabolism alterations in aged female mouse offspring

• Published in: American journal of physiology. Regulatory, integrative and comparative physiology Vol. 315; no. 6; pp. R1107 - R1114
• Main Authors: Stojanovska, Violeta, Sharma, Neha, Dijkstra, Dorieke J., Scherjon, Sicco A., Jäger, Andrea, Schorle, Hubert, Plösch, Torsten
• Format: Journal Article
• Language: English
• Published: United States American Physiological Society 01.12.2018
• Subjects: Adipose tissue; Animal models; Cholesterol; Cre recombinase; Deprivation; Diabetes mellitus; Diabetes mellitus (non-insulin dependent); Endoplasmic reticulum; Fatty acids; Fatty-acid synthase; Genetic crosses; Glucose; Homeostasis; Lipids; Lipogenesis; Liver; Metabolic disorders; Metabolism; Mice; Nutrient deficiency; Offspring; Phospholipids; Placenta; Regulators; Risk acceptance; Risk analysis; Risk factors; Rodents; Triglycerides; Uterus; intrauterine growth restriction; metabolic homeostasis; placental insufficiency; developmental programming

Intrauterine growth restriction (IUGR) is an accepted risk factor for metabolic disorders in later life, including obesity and type 2 diabetes. The level of metabolic dysregulation can vary between subjects and is dependent on the severity and the type of IUGR insult. Classical IUGR animal models in...