Causal associations of circulating Helicobacter pylori antibodies with stroke and the mediating role of inflammation

• Published in: Inflammation research Vol. 72; no. 6; pp. 1193 - 1202
• Main Authors: Guo, Xingzhi, Tang, Peng, Zhang, Xin, Li, Rui
• Format: Journal Article
• Language: English
• Published: Cham Springer International Publishing 01.06.2023; Springer Nature B.V
• Subjects: Allergology; Antibodies; Antigens, Bacterial - metabolism; Bacterial Proteins - genetics; Bacterial Proteins - metabolism; Biomedical and Life Sciences; Biomedicine; C-reactive protein; Dermatology; Genome-wide association studies; Genome-Wide Association Study; Genomes; Health risks; Helicobacter Infections - complications; Helicobacter pylori; Helicobacter pylori - genetics; Helicobacter pylori - metabolism; Humans; Immunology; Infections; Inflammation - complications; Monocyte chemoattractant protein; Monocyte chemoattractant protein 1; Monocytes; Neurology; Original Research Paper; Peptic ulcers; Pharmacology/Toxicology; Proteins; Rheumatology; Risk; Signal transduction; Stroke; Stroke - complications; Stroke; C-reactive protein; Vacuolating cytotoxin-A; Mendelian randomization; Helicobacter pylori

Background Observational studies have shown that Helicobacter pylori ( H. pylori ) infection and H. pylori antibodies are associated with an increased risk of stroke. However, which and how H. pylori antibodies serve as the causal determinant of the development of stroke remains largely unknown. Met...