Long non-coding RNA FKSG29 regulates oxidative stress and endothelial dysfunction in obstructive sleep apnea

• Published in: Molecular and cellular biochemistry Vol. 479; no. 10; pp. 2723 - 2740
• Main Authors: Chen, Yung-Che, Hsu, Po-Yuan, Su, Mao-Chang, Chen, Yung-Lung, Chang, Ya‐Ting, Chin, Chien-Hung, Lin, I.-Chun, Chen, Yu-Mu, Wang, Ting-Ya, Lin, Yong-Yong, Lee, Chiu-Ping, Lin, Meng-Chih, Hsiao, Chang-Chun
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.10.2024; Springer Nature B.V
• Subjects: Adult; Antioxidants; Apnea; Apoptosis; Biochemistry; Biomedical and Life Sciences; Cancer Research; Cardiology; CYBB protein; Endothelial cells; Endothelium, Vascular - metabolism; Endothelium, Vascular - pathology; Female; Gene expression; Genes; Human Umbilical Vein Endothelial Cells - metabolism; Humans; Hypertension; Hypoxia; Immunofluorescence; Intercellular adhesion molecule 1; Interleukin 6 receptors; Leukocytes (mononuclear); Life Sciences; Low density lipoprotein; Male; Medical Biochemistry; MicroRNAs - genetics; MicroRNAs - metabolism; Middle Aged; miRNA; Monocytes; NADPH Oxidase 2 - genetics; NADPH Oxidase 2 - metabolism; NADPH Oxidase 5 - genetics; NADPH Oxidase 5 - metabolism; Non-coding RNA; NOX4 protein; Oxidants; Oxidative Stress; Oxidizing agents; Oxygenation; Peripheral blood mononuclear cells; Regulations; Ribonucleic acid; RNA; RNA, Long Noncoding - genetics; RNA, Long Noncoding - metabolism; Sleep apnea; Sleep Apnea, Obstructive - genetics; Sleep Apnea, Obstructive - metabolism; Sleep disorders; Subgroups; Superoxide dismutase; THP-1 Cells; Umbilical vein; Up-regulation; Vascular Endothelial Growth Factor A; Vasoactive agents; Intermittent hypoxia; Endothelial dysfunction; FKSG29; miR-23a-3p; Obstructive sleep apnea; Long non-coding RNA

Altered expressions of pro-/anti-oxidant genes are known to regulate the pathophysiology of obstructive sleep apnea (OSA).We aim to explore the role of a novel long non-coding (lnc) RNA FKSG29 in the development of intermittent hypoxia with re-oxygenation (IHR)-induced endothelial dysfunction in OSA...