Multiomic Analysis Reveals Comprehensive Tumor Heterogeneity and Distinct Immune Subtypes in Multifocal Intrahepatic Cholangiocarcinoma

• Published in: Clinical cancer research Vol. 28; no. 9; pp. 1896 - 1910
• Main Authors: Chen, Shuling, Xie, Yubin, Cai, Yuhong, Hu, Huanjing, He, Minghui, Liu, Lijuan, Liao, Changyi, Wang, Yuanqi, Wang, Jianping, Ren, Xiaoxue, Zeng, Qianwen, Peng, Hong, Shen, Shunli, Li, Shaoqiang, Li, Dongming, Lai, Jiaming, Peng, Baogang, Ren, Jian, Kuang, Ming, Peng, Sui
• Format: Journal Article
• Language: English
• Published: United States 01.05.2022
• Subjects: Bile Duct Neoplasms - genetics; Bile Duct Neoplasms - pathology; Bile Ducts, Intrahepatic - pathology; Biomarkers, Tumor - genetics; Cholangiocarcinoma - genetics; Cholangiocarcinoma - pathology; Humans; Prognosis; Transcriptome; Whole Exome Sequencing

Targeted therapy and immunotherapy are transforming the treatment approach for intrahepatic cholangiocarcinoma (ICC). However, little is known about the intertumor heterogeneity (ITH) of multifocal ICC and its impacts on patient response to these treatments. We aimed to characterize the immunogenomi...