Protective Effects of Nicotinamide Adenine Dinucleotide and Related Precursors in Alzheimer’s Disease: A Systematic Review of Preclinical Studies

• Published in: Journal of molecular neuroscience Vol. 71; no. 7; pp. 1425 - 1435
• Main Authors: Hosseini, Leila, Mahmoudi, Javad, Pashazadeh, Fariba, Salehi-Pourmehr, Hanieh, Sadigh-Eteghad, Saeed
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.07.2021; Springer Nature B.V
• Subjects: Adenine; Alzheimer Disease - drug therapy; Alzheimer Disease - metabolism; Alzheimer's disease; Amyloid beta-Peptides - metabolism; Animal models; Animals; Anti-Inflammatory Agents - pharmacology; Anti-Inflammatory Agents - therapeutic use; Apoptosis; Apoptosis - drug effects; Attenuation; Behavior, Animal - drug effects; Bioenergetics; Biomedical and Life Sciences; Biomedicine; Cell Biology; Cognitive ability; Disease Models, Animal; Drug Evaluation, Preclinical; Energy Metabolism; Inflammation; Mice; Mice, Transgenic; Mitochondria; Mitochondria - physiology; NAD; NAD - pharmacology; NAD - therapeutic use; Neurochemistry; Neurodegenerative diseases; Neuroinflammatory Diseases - drug therapy; Neurology; Neuroprotection; Neuroprotective Agents - pharmacology; Neuroprotective Agents - therapeutic use; Neurosciences; Niacin - pharmacology; Niacinamide - pharmacology; Niacinamide - therapeutic use; Nicotinamide; Nicotinamide adenine dinucleotide; Oxidative stress; Oxidative Stress - drug effects; Precursors; Protein Aggregation, Pathological - prevention & control; Proteomics; Rats; Reviews; Rodents; Search engines; Search methods; Synapses - drug effects; Synapses - metabolism; Systematic review; tau Proteins - metabolism; Neuroprotection; Cognition; Nicotinamide; Alzheimer’s disease; Rodent

Data from preclinical studies propose nicotinamide adenine dinucleotide (NAD + ) as a neuroprotective and bioenergetics stimulant agent to treat Alzheimer’s disease (AD); however, there seems to be inconsistency between behavioral and molecular outcomes. We performed this systematic review to provid...