Is minimally invasive surgery for large gastric GIST actually safe? A comparative analysis of short- and long-term outcomes

• Published in: Surgical endoscopy Vol. 36; no. 9; pp. 6975 - 6983
• Main Authors: Crocker, Andrew B., Vega, Eduardo A., Kutlu, Onur C., Salehi, Omid, Mellado, Sebastian, Li, Mu, Kozyreva, Olga, Conrad, Claudius
• Format: Journal Article
• Language: English
• Published: New York Springer US 01.09.2022; Springer Nature B.V
• Subjects: 2021 SAGES Oral; Abdominal Surgery; Gastrectomy; Gastroenterology; Gastrointestinal cancer; Gastrointestinal Stromal Tumors - pathology; Gynecology; Hepatology; Humans; Laparoscopy; Length of Stay; Medicine; Medicine & Public Health; Minimally Invasive Surgical Procedures; Mortality; Proctology; Retrospective Studies; Stomach Neoplasms - pathology; Stomach Neoplasms - surgery; Surgery; Survival analysis; Treatment Outcome; Tumors; Laparoscopic; Overall survival; MIS; Mortality; Morbidity; Gastric GIST
• ISSN: 0930-2794; 1432-2218
• DOI: 10.1007/s00464-022-09066-4

Introduction While minimally invasive surgery (MIS) is frequently utilized to remove small gastric gastrointestinal stromal tumors (GIST), MIS surgery for tumors ≥ 5 cm is currently not endorsed by national guidelines as standard of care due to concerns of safety and inferior oncologic outcomes. Hence this study investigates the perioperative and long-term outcomes of MIS for T3 gastric GIST measuring 5–10 cm. Methods The National Cancer Database (NCDB) 2017 was queried for gastric GIST measuring 5–10 cm or T3 category. Inclusion criteria were known: stage, size, comorbidities, grade, lymphovascular invasion, type of surgery, approach, conversion info, margin status, mitotic rate, neoadjuvant and adjuvant treatment, hospital stay, readmission, 30- and 90-day mortality, complete follow-up, type of institution, and hospital gastric surgery case volume. Binary logistic regression, linear regression models, and Kaplan–Meier survival analysis were used. Results In 3765 patients, mean tumor size was 67.3 mm; 26.3% MIS; and 73.8% open. Median hospital stay was shorter for MIS (4.77 vs 7.04 days, p  < 0.001). There was no significant difference in incidence of R1 margins [2.9% MIS vs. 3.1% open ( p  = 0.143)], unplanned readmission [2.9% MIS and 4.1% open (OR 0.474 p  = 0.025)], 30-day mortality [0.5% MIS vs 1.2% open (OR 0.325, p  = 0.031)], and 90-day mortality [0.9% MIS vs 2.1% open (OR 0.478 p  = 0.036)]. Cox regression models for OS showed no difference in survival ( p  = 0.137, HR 0.808). Conclusion This analysis provides substantial evidence that MIS for gastric GIST ≥ 5–10 cm may not only offer improved postoperative morbidity but also oncologic safety. Moreover, as both approaches lead to similar long-term survival, national guidelines may need to incorporate this new information. Graphical abstract