Impact of ecological UV radiation on the photochemistry of nuclear DNA

• Published in: Biophysical reviews Vol. 17; no. 2; pp. 537 - 545
• Main Authors: Sánchez, Ana G., Gabrielli, Adriana, Keszenman, Deborah J.
• Format: Journal Article
• Language: English
• Published: Berlin/Heidelberg Springer Berlin Heidelberg 01.04.2025; Springer Nature B.V
• Subjects: 8-Hydroxyguanine; Biochemistry; Biological and Medical Physics; Biological effects; Biological Techniques; Biomedical and Life Sciences; Biophysics; Carbonyls; Cell Biology; Cyclobutane; Cyclobutane pyrimidine dimers; Damage; DNA damage; Energy transfer; Exposure; Isomers; Life Sciences; Melanin; Melanocytes; Membrane Biology; NAD(P)H oxidase; Nanotechnology; Nitric oxide; Nitric-oxide synthase; Peroxynitrite; Photochemistry; Photosensitization; pyrimidine (6-4) pyrimidone; Pyrimidines; Radiation sources; Reactive oxygen species; Review; Singlet oxygen; Solar radiation; Ultraviolet radiation; 8-OxoG; CPDs; 6-4PP; 8-NitroG; Dewar isomers; UVA/UVB radiation

Solar radiation is predominantly Earth’s natural ultraviolet (UV) radiation source. The biological effects of UV radiation have been the subject of scientific interest for decades. The most frequent and abundant types of DNA damage comprise the formation of cyclobutane pyrimidine dimers (CPDs) and p...