A non-human primate model for human norovirus infection

• Published in: Nature microbiology Vol. 9; no. 3; pp. 776 - 786
• Main Authors: Rimkute, Inga, Chaimongkol, Natthawan, Woods, Kamron D., Nagata, Bianca M., Darko, Samuel, Gudbole, Sucheta, Henry, Amy R., Sosnovtsev, Stanislav V., Olia, Adam S., Verardi, Raffaello, Bok, Karin, Todd, John-Paul, Woodward, Ruth, Kwong, Peter D., Douek, Daniel C., Alves, Derron A., Green, Kim Y., Roederer, Mario
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01.03.2024; Nature Publishing Group
• Subjects: 14/32; 14/63; 631/250/255/2514; 631/326/596/2555; 64; 82/1; 82/51; Animal models; Biomedical and Life Sciences; Biopsy; Cell surface; Epithelial cells; Gastrointestinal diseases; Glycosylation; Immune response; Infections; Infectious Diseases; Jejunum; Life Sciences; Medical Microbiology; Microbiology; Oral infection; Parasitology; Small intestine; Vaccines; Virology; Viruses

Norovirus infection can cause gastrointestinal disease in humans. Development of therapies and vaccines against norovirus have been limited by the lack of a suitable and reliable animal model. Here we established rhesus macaques as an animal model for human norovirus infection. We show that rhesus m...